机构：[1]Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China[2]Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China广东省人民医院[3]The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China[4]Maoming People’s Hospital, Maoming, China[5]Shunde Hospital of Southern Medical University, Shunde, China[6]Department of Cardiology, Dongguan TCM Hospital, Dongguan 523209, China[7]Department of Cardiology, First People’s Hospital of Kashgar, Kashgar 844000, China[8]Department of Information Technology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Malnutrition is a common comorbidity of coronary artery disease (CAD) and is often associated with adverse events. The malnutrition often means lower cholesterol, albumin and high lymphocyte, as risk factors of Contrast-Induced Acute Kidney Injury (CI-AKI). We aim to evaluate the association between malnutrition and CI-AKI following coronary angiography (CAG) in CAD patients.We analyzed 3170 CAD patients with variables of nutritional status (Controlling Nutritional Status score (CONUT)) from the prospective multicenter study, REICIN (NCT01402232) including 4,271 consecutive patients undergoing CAG from January 2013 to February 2016. Patients were divided into the normal group (CONUT score 0-1) and malnutrition group (CONUT score > 1). The association of malnutrition and the risk of CI-AKI was examined in all CAD patients using multivariable logistics regression analysis.Among the 3170 patients (mean age: 63.1 ± 10.7 years), 1865 (58.8%) suffered from malnutrition, 111 (3.5%) developed CI-AKI, including 23 (1.76%) in normal group and 88 (4.72%) in malnutrition group (p < 0.01). The malnourished patients were older, and likely had anemia and worse cardiorenal function. After adjustment for confounders, the risk of CI-AKI was 1.04 times higher in the malnutrition group than in the normal group (adjusted OR: 2.04, 95% CI 1.28-3.38, p < 0.01).Among CAD patients undergoing CAG, malnutrition is extremely common and associated with a double risk of CI-AKI. Further studies are needed to investigate the potential renal protection of intervening malnutrition in CAD patients.
基金：
This study was supported by grants from the Beijing Lisheng
Cardiovascular Health Foundation and Guangdong Provincial People’s
Hospital Foundation (LHJJ20141751) and the National Science
Foundation of China (81670339, 81970311) and Medical Scientific
Research Foundation of Guangdong Province (A2019414). The funders
had no role in the study design, data collection and analysis, decision
to publish, or preparation of the manuscript; the work was not funded
by any industry sponsors.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区泌尿学与肾脏学
最新[2025]版：
大类|4 区医学
小类|4 区泌尿学与肾脏学
第一作者：
第一作者机构：[1]Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Liling,Huang Zhidong,Li Weiguo,et al.Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease.[J].International Urology And Nephrology.2021,doi:10.1007/s11255-021-02915-6.
APA：
Chen Liling,Huang Zhidong,Li Weiguo,He Yibo,Liang Jingjing...&Chen Shiqun.(2021).Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease..International Urology And Nephrology,,
MLA：
Chen Liling,et al."Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease.".International Urology And Nephrology .(2021)
