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Rescued from desperation: adult-onset Still's disease with life-threatening interstitial lung disease and macrophage activation : Successful treatment by Tocilizumab.

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机构： [1]State Key Laboratory of Quality Research in ChineseMedicine/Macau Institute for Applied Research in Medicine and Health,Macau University of Science and Technology, Macau, China [2]Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Guangfeng Zhang andWenxue Liu contributed equally to this article as co-first authors. Xiao Zhang and Liang Liu contributed equally to this article as co-correspondingauthors. ScanQRcode&readarticleonline

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This article presents a case of fulminant interstitial lung disease (ILD) with macrophage activation syndrome (MAS) as a rare complication of adult-onset Still's disease in a 43-year-old male patient. Initial presentation showed severe ILD. Early treatment focused on high-dose corticosteroids; however, disease remission could not be achieved. After an additional inflammatory focus and underlying malignancy were excluded, the triad of pancytopenia, fever, and high ferritin levels indicated MAS; bone marrow biopsy confirmed secondary hemophagocytic histiocytosis. Treatment with tocilizumab induced fast and effective therapeutic success.© 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区风湿病学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区风湿病学

第一作者：

第一作者机构： [1]State Key Laboratory of Quality Research in ChineseMedicine/Macau Institute for Applied Research in Medicine and Health,Macau University of Science and Technology, Macau, China [2]Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Guangfeng Zhang andWenxue Liu contributed equally to this article as co-first authors. Xiao Zhang and Liang Liu contributed equally to this article as co-correspondingauthors. ScanQRcode&readarticleonline

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通讯机构： [1]State Key Laboratory of Quality Research in ChineseMedicine/Macau Institute for Applied Research in Medicine and Health,Macau University of Science and Technology, Macau, China [*1]State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology 999078 Macau, China

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