4D-quantitative proteomics signature of asthenozoospermia and identification of extracellular matrix protein 1 as a novel biomarker for sperm motility.
机构：[1]Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036, P. R. China北京大学深圳医院深圳医学信息中心香港大学深圳医院[2]Reproductive Medicine Center, Peking University Shenzhen Hospital, P. R. China.北京大学深圳医院深圳医学信息中心[3]Medical Laboratory Department, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, P. R. China.广州中医药大学深圳医院深圳市康宁医院深圳医学信息中心
Asthenozoospermia (AZS), diagnosed by reduced sperm motility, is one of the major causes of male infertility. However, AZS has no effective therapeutic treatment and the underlying molecular mechanism remains largely unclear. In this study, state-of-the-art 4D-quantitative proteomics analysis was used to compare the protein profiling between 7 normozoospermic and 11 asthenozoospermic sperm samples. Overall, 4718 proteins were identified and 1430 differential abundant proteins were found in the two groups. The differentially expressed proteins were analyzed by GO and KEGG. The core deregulated proteins and pathways associated sperm motility dysfunction included energy metabolism and the sperm structure. Integrative analysis further identified extracellular matrix protein 1 (ECM1) as a novel biomarker related to AZS. Our study could provide new insights into the molecular basis of low sperm motility. The mass spectrometric data are available via ProteomeXchange with identifier PXD027637.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区生物
小类|3 区生化与分子生物学
最新[2025]版：
大类|4 区生物学
小类|4 区生化与分子生物学
第一作者：
第一作者机构：[1]Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036, P. R. China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Jie,Liu Qunlong,Yu Bohai,et al.4D-quantitative proteomics signature of asthenozoospermia and identification of extracellular matrix protein 1 as a novel biomarker for sperm motility.[J].Molecular Omics.2021,doi:10.1039/d1mo00257k.
APA：
Yang Jie,Liu Qunlong,Yu Bohai,Han Baoquan&Yang Bo.(2021).4D-quantitative proteomics signature of asthenozoospermia and identification of extracellular matrix protein 1 as a novel biomarker for sperm motility..Molecular Omics,,
MLA：
Yang Jie,et al."4D-quantitative proteomics signature of asthenozoospermia and identification of extracellular matrix protein 1 as a novel biomarker for sperm motility.".Molecular Omics .(2021)
