机构：[1]Department of Clinical Laboratory, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.[2]Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.[3]Department of Clinical Laboratory, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, Liuzhou,Guangxi, China.[4]Department of Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-sen University·Yuedong Hospital, Meizhou, Guangdong, China.中山大学附属第三医院
WNT16 is one of the 19 members of the human Wnt gene family, and it plays a positive role in lymphocyte proliferation. We investigated the possible association of WNT16 rs3801385 and rs2707466 with the CD4+ T cell count among the HIV-infected population in Guangxi, China. A total of 93 HIV-1-infected patients aged 20-75 years were separated into a CD4+ T cell count ≥200/mm3 group (60 cases) and a <200/mm3 group (33 cases), and 76 healthy subjects were selected as the control group. All patients have not received any antiretroviral treatment. Direct sequencing was used to detect two functional WNT16 polymorphisms. After adjusting for age and gender, our results showed that rs2707466 A alleles and combined GA+AA genotypes were associated with a CD4+ T cell count maintained ≥200/mm3 in the context of HIV infections compared with the control group (odds ratio [OR] = 2.22, 95% confidence interval [CI]: 1.10-4.48, p = .026, and OR = 2.33, 95% CI: 1.03-5.29, p = .044, respectively). When stratified by viral load, this positive association was significantly strengthened in the viral load group of <20 copies/mL. In contrast, there was no significant difference in any genotype and allele of rs3801385 between the patients and healthy controls. In conclusion, the results suggest that the rs2707466 A allele may have a positive effect on maintaining the CD4+ T cell count in HIV-infected individuals.
基金：
This work was supported by the Youth Science Foundation Project of Guangxi Natural
Science Foundation(No. 2017GXNSFBA198068).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区免疫学4 区传染病学4 区病毒学
最新[2025]版：
大类|4 区医学
小类|4 区免疫学4 区传染病学4 区病毒学
第一作者：
第一作者机构：[1]Department of Clinical Laboratory, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
共同第一作者：
通讯作者：
通讯机构：[2]Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.[*1]Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, No. 6, Shuang Yong Road, Nanning 530021, Guangxi, China.
推荐引用方式(GB/T 7714)：
Xie Li,Huang Yiyong,Zhong Jianing,et al.Short Communication: The Association of WNT16 Polymorphisms with the CD4+ T Cell Count in the HIV-Infected Population.[J].AIDS Research And Human Retroviruses.2020,36(2):119-121.doi:10.1089/AID.2019.0038.
APA：
Xie Li,Huang Yiyong,Zhong Jianing,Wei Huiping,Chen Siyuan...&Qin Xue.(2020).Short Communication: The Association of WNT16 Polymorphisms with the CD4+ T Cell Count in the HIV-Infected Population..AIDS Research And Human Retroviruses,36,(2)
MLA：
Xie Li,et al."Short Communication: The Association of WNT16 Polymorphisms with the CD4+ T Cell Count in the HIV-Infected Population.".AIDS Research And Human Retroviruses 36..2(2020):119-121
