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Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccines.

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收录情况： ◇ ESCI

作者：
Yufang Zhu[1] * ; Yingying Lu[2,3] * ; Caili Zhou[1] * ; Gangling Tong[4] * ; Manman Gao[5,6] * ; Yan Zhan[7] * ; Yan Wang[8] * ; Ran Liang[1] ; Yawei Li[1] ; Tianjiao Gao[1] ; Li Wang[1] ; Muyun Zhang[1] ; Jin Cheng[9] ; Jun Gong[10] ; Jimin Wang[11] ; Wei Zhang[12] ; Junhua Qi[13] ; Miao Cui[14] ; Longchao Zhu[15] ; Fenglian Xiao[16] ; Linyu Zhu[17] ; Yunsheng Xu[12,17] ; Zhihua Zheng[2] ; Zhiyu Zhou[5,18] ; Zhengjiang Cheng[1] ; Peng Hong[2,19,20] ;
机构： [1]Laboratory of Clinical Immunology, Division ofLaboratory Medicine, Xiangyang CentralHospital, Affiliated Hospital of Hubei University ofArts and Science, Xiangyang, Hubei, China [2]Center for Kidney Diseases, Department ofNephrology, The Seventh Affiliated Hospital, SunYat-sen University, Shenzhen, Guangdong,China [3]Department of Biomedical Science, ShenzhenResearch Institute, City University of Hong Kong,Kowloon Tong, Hong Kong, China [4]Department of Oncology, Peking UniversityShenzhen Hospital, Shenzhen, Guangdong,China [5]Innovation Platform of Regeneration and Repairof Spinal Cord and Nerve Injury, Department ofOrthopedic Surgery, The Seventh AffiliatedHospital, Sun Yat-sen University, Shenzhen,Guangdong, China [6]Institute of Translational Medicine, Departmentof Sport Medicine, The First Affiliated Hospital ofShenzhen University, Shenzhen Second People’sHospital, Shenzhen, Guangdong, China [7]Department of Rehabilitation Medicine,Xiangyang Central Hospital, Affiliated Hospital ofHubei University of Arts and Science, Xiangyang,Hubei, China [8]Department of Obstetrics and Gynecology,Nanping First Hospital Affiliated to FujianMedical University, Nanping, Fujian, China [9]Department of Research Affairs, XiangyangCentral Hospital, Affiliated Hospital of HubeiUniversity of Arts and Science, Xiangyang, Hubei,China [10]Department of Orthopedic Surgery, XiangyangCentral Hospital, Affiliated Hospital of HubeiUniversity of Arts and Science, Xiangyang, Hubei,China [11]Department of Traditional Chinese Medicine,Xiangyang Central Hospital, Affiliated Hospital ofHubei University of Arts and Science, Xiangyang,Hubei, China [12]Department of Research Affairs, The SeventhAffiliated Hospital, Sun Yat-sen University,Shenzhen, Guangdong, China [13]Department of Laboratory Medicine, TheSeventh Affiliated Hospital, Sun Yat-senUniversity, Shenzhen, Guangdong, China [14]Department of Pathology, Mount Sinai St.Luke’s Roosevelt Hospital Center, New York, NY10025, USA [15]Institute of Infectious Diseases, Shenzhen BayLaboratory, Shenzhen, Guangdong, China [16]Nanfang College, Guangzhou, Guangdong,China [17]Department of Dermatology, The SeventhAffiliated Hospital, Sun Yat-sen University,Shenzhen, Guangdong, China [18]Guangdong Provincial Key Laboratory ofOrthopedics and Traumatology, The FirstAffiliated Hospital of Sun Yat-sen University,Guangzhou, Guangdong, China [19]Division of Research and Development, USDepartment of Veterans Affairs New York HarborHealthcare System, Brooklyn, NY 11209, USA [20]Department of Cell Biology, State University ofNew York Downstate Health Sciences University,Brooklyn, NY 11203, USA
出处：
DOI： 10.1016/j.medj.2022.05.003
ISSN：

摘要：
Emerging evidence suggests heterologous prime-boost COVID-19 vaccination as a superior strategy than homologous schedules. Animal experiments and clinical observations have shown enhanced antibody response against influenza variants after heterologous vaccination; however, whether the inoculation order of COVID-19 vaccines in a prime-boost schedule affects antibody response against SARS-CoV-2 variants is not clear.We conducted immunological analyses in a cohort of health care workers (n = 486) recently vaccinated by three types of inactivated COVID-19 vaccines under homologous or heterologous prime-boost schedules. Antibody response against ancestral SARS-CoV-2 (Wuhan-Hu-1) was assessed by total antibody measurements, surrogate virus neutralization tests, and pseudovirus neutralization assays (PNA). Furthermore, serum neutralization activity against SARS-CoV-2 variants of concern was also measured by PNA.We observed strongest serum neutralization activity against the widely circulating SARS-CoV-2 variant B.1.617.2 among recipients of heterologous BBIBP-CorV/CoronaVac and WIBP-CorV/CoronaVac. In contrast, recipients of CoronaVac/BBIBP-CorV and CoronaVac/WIBP-CorV showed significantly lower B.1.617.2 neutralization titers than recipients of reverse schedules. Laboratory tests revealed that neutralizing activity against common variants but not the ancestral SARS-CoV-2 was associated with the inoculation order of heterologous prime-boost vaccines. Multivariable regression analyses confirmed this association after adjusting for known confounders.Our data provide clinical evidence of inoculation order-dependent expansion of neutralizing breadth against SARS-CoV-2 in recipients of heterologous prime-boost vaccination and call for further studies into its underlying mechanism.National Key R&D Program of China, National Development and Re-form Commission of China, National Natural Science Foundation of China, Shenzhen Science and Technology Innovation Commission, and US Department of Veterans Affairs.Copyright © 2022 Elsevier Inc. All rights reserved.

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大类 | 1 区 医学
小类 | 1 区 医学：研究与实验
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Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版]

第一作者：
第一作者机构： [1]Laboratory of Clinical Immunology, Division ofLaboratory Medicine, Xiangyang CentralHospital, Affiliated Hospital of Hubei University ofArts and Science, Xiangyang, Hubei, China
共同第一作者：
通讯作者：
通讯机构： [2]Center for Kidney Diseases, Department ofNephrology, The Seventh Affiliated Hospital, SunYat-sen University, Shenzhen, Guangdong,China [5]Innovation Platform of Regeneration and Repairof Spinal Cord and Nerve Injury, Department ofOrthopedic Surgery, The Seventh AffiliatedHospital, Sun Yat-sen University, Shenzhen,Guangdong, China [18]Guangdong Provincial Key Laboratory ofOrthopedics and Traumatology, The FirstAffiliated Hospital of Sun Yat-sen University,Guangzhou, Guangdong, China [19]Division of Research and Development, USDepartment of Veterans Affairs New York HarborHealthcare System, Brooklyn, NY 11209, USA [20]Department of Cell Biology, State University ofNew York Downstate Health Sciences University,Brooklyn, NY 11203, USA
推荐引用方式(GB/T 7714)：
Yufang Zhu,Yingying Lu,Caili Zhou,et al.Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccines.[J].MED.2022,3(8):568-+.doi:10.1016/j.medj.2022.05.003.
APA：
Yufang Zhu,Yingying Lu,Caili Zhou,Gangling Tong,Manman Gao...&Peng Hong.(2022).Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccines..MED,3,(8)
MLA：
Yufang Zhu,et al."Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccines.".MED 3..8(2022):568-+

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