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Diselenide-crosslinked carboxymethyl chitosan nanoparticles for doxorubicin delivery: Preparation and in vivo evaluation.

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机构： [1]School of Medicine, Foshan University, Foshan 528000, Guangdong, PR China [2]Department of Statistics, University of California, Riverside, 900 University Ave., Riverside, CA 92521, USA [3]Hospital of Chinese Traditional Medicine of Guangdong Province, Foshan 528000, Guangdong, PR China

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关键词： Diselenide Disulfide Nanoparticles Carboxymethyl chitosan Drug delivery

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In this paper, we report a simple approach to fabricate diselenide-crosslinked carboxymethyl chitosan nanoparticles (DSe-CMC NPs) for doxorubicin (DOX) delivery, with disulfide analogs (DS-CMC NPs) as control. DS-CMC NPs and DSe-CMC NPs featured a spherical morphology and narrow size distribution with the average size about 200 nm. Carboxymethyl chitosan (CMC) as the starting material not only improved the biocompatibility of the nanocarriers but also enhanced physiological stability. Due to electrostatic interactions between DOX and CMC, the nanoparticles had high drug encapsulation efficiency (∼25 %). The nanoparticles disintegration and drug release were accelerated by the cleavage of diselenide bonds through oxidation by H2O2 or reduction by GSH. In vitro cell experiments revealed that DOX-loaded DSe-CMC NPs possessed the highest drug accumulation and cytotoxicity in tumor cells. Moreover, DOX-loaded DSe-CMC NPs performed the enhanced growth inhibition in vivo than that of DS-CMC NPs. Thus, the diselenide-crosslinked nanoparticles possess great potentials for DOX delivery.Copyright © 2022 Elsevier Ltd. All rights reserved.

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出版当年[2021]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区有机化学 1 区高分子科学

最新[2025]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区有机化学 1 区高分子科学

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第一作者机构： [1]School of Medicine, Foshan University, Foshan 528000, Guangdong, PR China

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