机构：[1]Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rheumatol, Hengyang 421001, Hunan, Peoples R China[2]Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hengyang 421001, Hunan, Peoples R China[3]Univ South China, Hengyang Med Sch, Key Lab Special Pathogen Prevent & Control Hunan, Hengyang 421001, Hunan, Peoples R China[4]Hainan Med Univ, Affiliated Hosp 2, Dept Clin Lab, Haikou 570216, Hainan, Peoples R China[5]Shenzhen Tradit Chinese Med Hosp, Dept Clin Lab, Shenzhen 518033, Guangdong, Peoples R China
Autophagy is a lysosomal degradation pathway that depends on various evolutionarily conserved autophagy-related genes (ATGs). Dysregulation of autophagy plays an important role in the occurrence and development of cancer. Chemotherapy, targeted therapy, radiotherapy, and immunotherapy are important treatment options for cancer, which can significantly improve the survival rate of cancer patients. However, the occurrence of therapy resistance results in therapeutic failure and poor prognosis of cancer. Accumulating studies have found that long non-coding RNAs (lncRNAs) are well known as crucial regulators to control autophagy through regulating ATGs and autophagy-associated signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway, ultimately mediating chemoresistance and radioresistance. Taken together, this review systematically summarizes and elucidates the pivotal role of lncRNAs in cancer chemoresistance and radioresistance via regulating autophagy. Understanding the specific mechanism of which may provide autophagy-related therapeutic targets for cancer in the future.
基金：
National Natural Science Foundation of China [81870105, 82170138]; Scientific Research Fund Project of Hunan Provincial Health Commission [20201921]; Natural Science Foundation of Hunan Province [2021JJ30022]
第一作者机构：[1]Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rheumatol, Hengyang 421001, Hunan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rheumatol, Hengyang 421001, Hunan, Peoples R China[5]Shenzhen Tradit Chinese Med Hosp, Dept Clin Lab, Shenzhen 518033, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Yanyan,Liu Zhaoping,Xu Zhenru,et al.Introduction of long non-coding RNAs to regulate autophagy-associated therapy resistance in cancer[J].MOLECULAR BIOLOGY REPORTS.2022,49(11):10761-10773.doi:10.1007/s11033-022-07669-7.
APA：
Wang, Yanyan,Liu, Zhaoping,Xu, Zhenru,Shao, Wenjun,Hu, Dingyu...&Zhang, Ji.(2022).Introduction of long non-coding RNAs to regulate autophagy-associated therapy resistance in cancer.MOLECULAR BIOLOGY REPORTS,49,(11)
MLA：
Wang, Yanyan,et al."Introduction of long non-coding RNAs to regulate autophagy-associated therapy resistance in cancer".MOLECULAR BIOLOGY REPORTS 49..11(2022):10761-10773
