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Mechanistic insights and implications of FOXO-SNAI interplay

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机构： [1]School of Medicine, Hunan Normal University, Changsha, Hunan, China. [2]Institute of Intervention Vessel, Shanghai 10th People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, China. [3]College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, Hebei, China. [4]School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. [5]Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Guangdong, China.

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Autophagy promotes both health and disease, depending on tissue types and genetic contexts, yet the regulatory mechanism remain incompletely understood. Our recent publication has uncovered a coherent FOXO-SNAI feed-forward loop in autophagy, which is evolutionarily conserved from Drosophila to human. In addition, it's revealed that DNA binding plays a critical role in intracellular localization of nucleocytoplasmic shuttling proteins. Based on these findings, herein we further integrate mechanistic insights of FOXO-SNAI regulatory interplay in autophagy and unravel the potential link of FOXO-induced autophagy with SNAI in diseases. Besides, the generality of DNA-retention mechanism on transcription factor nuclear localization is illustrated with wide-ranging discussion, and more functions potentially regulated by FOXO-SNAI feedforward loop are provided. Elucidation of these unsolved paradigms will expand the understanding of FOXO-SNAI interplay and facilitate the development of new therapeutics targeting FOXO-SNAI axis in diseases.© 2022 Wiley Periodicals LLC.

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出版当年[2021]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 3 区生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生物学 4 区生化与分子生物学

第一作者：

第一作者机构： [1]School of Medicine, Hunan Normal University, Changsha, Hunan, China. [2]Institute of Intervention Vessel, Shanghai 10th People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, China. [*1]Institute of Intervention Vessel, Shanghai 10th People’s Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.

通讯作者：

通讯机构： [1]School of Medicine, Hunan Normal University, Changsha, Hunan, China. [2]Institute of Intervention Vessel, Shanghai 10th People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, China. [5]Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Guangdong, China. [*1]Institute of Intervention Vessel, Shanghai 10th People’s Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.

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