The genus Elsholtzia (family Labiaceae) is an important source of folk traditional Chinese medicine, mainly used to relieve the symptoms of cold, fever, pneumonia and so on. However, currently available data on its traditional and pharmacological advantages have not been comprehensively reviewed.This review provides up-to-date and comprehensive information on the ethnopharmacological, phytochemical, pharmacological properties and toxicity of Elsholtzia, highlights the antibacterial, antiviral, and anti-inflammatory advantages of the genus, and explores its therapeutic potential.Use Google Scholar, Scifinder, PubMed, Springer, Elsevier, Wiley, Web of Science and other online database search to collect the research literatures on application, chemistry and biological activity of Elsholtzia published before December 2021. Their scientific names have been verified using The Plant List and World Flora Online websites.A total of 42 species of Elsholtzia are widely distributed all over the world, especially in Yunnan Province (China). Since Elsholtzia genus is commonly used in the folk to treat respiratory infectious diseases such as cold and fever, growing numbers of studies have confirmed their antiviral, antibacterial and anti-inflammatory activities. So far, about 221 non-volatile compounds and 1008 volatile compounds have been identified from Elsholtzia plants, mainly containing flavonoids and terpenoids showing convincing antibacterial, antiviral and anti-inflammatory activities. Further research found that their antibacterial and antiviral spectrums are broad, and volatile oils are considered to be the main antibacterial components. Their anti-inflammatory mechanism is mainly through the inhibition of NF-κB and MAPKs signaling pathways. Toxicological studies have not established its toxicity.By summarizing the latest information on genus Elsholtzia, their traditional uses, material basis and mechanisms of action in antiviral, antibacterial and anti-inflammatory aspects were described, providing new insights for the genus and its importance as a potential natural resource of antiviral and anti-inflammatory drugs, giving evidence and new ideas for the development of herbal medicines.Copyright © 2022. Published by Elsevier B.V.