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The potential performance of serum albumin to globulin ratio, albumin and globulin in the diagnosis of periprosthetic joint infection and prediction of reinfection following reimplantation

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机构: [1]The First Clinical of Medical School, Guangzhou University of ChineseMedicine, NO.12 Jichang Road, District Baiyun, Guangzhou 510405, Guangdong,China [2]The First Department of Orthopedics, Jiangxi Province Hospitalof Integrated Chinese and Western Medicine, NO.90 Bayi Road, District Xihu,Nanchang 330003, Jiangxi, China [3]Department of Orthopaedics, The FirstAffiliated Hospital of Guangzhou University of Chinese Medicine, NO.16 JichangRoad, District Baiyun, Guangzhou 510405, Guangdong, China [4]The TenthDepartment of Orthopedics, Foshan Hospital of Chinese Medicine, NO.6 QinrenRoad, District Chancheng, Foshan 528000, Guangdong, China [5]The Directorof the Orthopedic Department of, Guangdong Province Hospital of TraditionalChinese Medicine, NO.111 Dade Road, District Yuexiu, Guangzhou 510000,Guangdong, China [6]The Affiliated Hospital of Jiangxi University of TraditionalChinese Medicine, No.445 Bayi Avenue, Nanchang 330000, Jiangxi, China.
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This study was conducted to evaluate the performance of serum albumin (ALB), globulin (GLO), and albumin to globulin ratio (AGR) in the diagnosis of PJI and prediction of reinfection following reimplantation in PJI patients who underwent two-stage revision.We perform a retrospective data collection on identified patients who underwent revision arthroplasties in our institution from January 2010 to January 2020. A total of 241 patients were stratified into: group A (PJI), group B (aseptic loosening). Fifty-five patients who underwent two-stage revision in group A were assigned to group C. Group C was stratified into subgroup 1 (reinfection) and subgroup 2 (non-reinfection). Receiver operating characteristic curves were used to evaluate the utility of serum markers for diagnosing PJI and predicting reinfection following reimplantation.In the diagnosis of PJI, there were significant differences in the levels of ALB, GLO, and AGR between groups A and group B (P < 0.05). The AUC value of serum AGR (0.851) was similar to ESR (0.841) and CRP (0.866) (all p > 0.05). The AUC values of serum ALB and GLO were 0.757 and 0.753, respectively. As for predicting reinfection following reimplantation, the serum ALB in the non-reinfection group was higher than that in the reinfection group (p = 0.041). The AUC value of serum ALB was 0.7.AGR was promising adjunct marker for the diagnosis of PJI, similar to CRP and ESR. ALB and GLO have an acceptable value for the diagnosis of PJI. ALB may be expected to be a kind of effective marker for predicting reinfection following reimplantation.© 2022. The Author(s).

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出版当年[2021]版:
大类 | 3 区 医学
小类 | 4 区 骨科 4 区 风湿病学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 骨科 3 区 风湿病学
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出版当年[2020]版:
Q3 ORTHOPEDICS Q4 RHEUMATOLOGY
最新[2023]版:
Q2 ORTHOPEDICS Q3 RHEUMATOLOGY

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第一作者机构: [1]The First Clinical of Medical School, Guangzhou University of ChineseMedicine, NO.12 Jichang Road, District Baiyun, Guangzhou 510405, Guangdong,China
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