详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Three polymethoxyflavones from the peel of Citrus reticulata Chachi inhibits oxidized low-density lipoprotein-induced macrophage-derived foam cell formation

12| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China. [2]School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China. [3]State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China. [4]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. [5]Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

出处：

DOI：

ISSN：

关键词： atherosclerosis polymethoxyflavones foam cells inflammation lipid metabolism

摘要：

Foam cell formation is the hallmark of the development and progression of atherosclerosis. The aim of this study was to investigate the regulatory effects of three polymethoxyflavones (PMFs), namely, tangeretin (TAN), 5,6,7,3',4',5'-hexamethoxyflavone (HxMF), and 3,5,6,7,8,3',4'-heptamethoxyflavone (HpMF) on macrophage-derived foam cell formation and to further explore the molecular mechanisms. The RAW264.7 macrophage-derived foam cell model was successfully induced by oxidized low-density lipoprotein (ox-LDL) (80 μg/ml). It showed that TAN, HxMF, and HpMF alleviated ox-LDL-induced NO release while also inhibiting the expression of IL-1β, IL-6, and TNF-α in RAW264.7 cells. Uptake of excess ox-LDL was inhibited by TAN, HxMF, and HpMF, resulting in the reduction of its foam cell formation. Moreover, TAN, HxMF, and HpMF promoted HDL-mediated cholesterol efflux. Western blot experiment showed that TAN, HxMF, and HpMF inhibited the expression of scavenger receptor class A type I (SRA1) and cluster of differentiation 36 (CD36), while upregulating peroxisome proliferator-activated receptor γ (PPARγ), liver X receptor α (LXRα), phospholipid ATP-binding cassette transporter G1 (ABCG1), and scavenger receptor class B type I (SRB1) expression. Together, our findings suggested that PMFs inhibited foam cell formation might inhibit lipid uptake via downregulating SRA1/CD36 expression and promote cholesterol efflux from foam cells via upregulating PPARγ/LXRα/ABCG1/SRB1 expression. This antiatherosclerotic activity is expected to provide new insights into the development of healthcare uses for PMFs.Copyright © 2022 Liang, Liang, He, Chen, Xu, Tu, Zhang, Qiu, Zhang, Huang and Xu.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区心脏和心血管系统

最新[2025]版：

大类 | 3 区医学

小类 | 3 区心脏和心血管系统

JCR分区：

出版当年[2020]版：

Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

最新[2023]版：

Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

影响因子： 2.8 最新[2023版] 3.1 最新五年平均 6.05 出版当年[2020版] 0 出版当年五年平均 3.915 出版前一年[2019版] 5.848 出版后一年[2021版]

第一作者：

第一作者机构： [1]Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.

通讯作者：

通讯机构： [1]Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China. [5]Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Psoriasis comorbid with atherosclerosis meets in lipid metabolism [2]Lipid metabolism and rheumatoid arthritis [3]Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation. [4]Experimental Study of Yishou Tiaozhi Tablet(益寿调脂片) on Inhibiting Hyperlipemia and Atherosclerosis [5]RAGE promotes dysregulation of iron and lipid metabolism in alcoholic liver disease [6]穗花杉双黄酮激活PPAR-α/γ抑制THP-1源性巨噬细胞向M1型极化 [7]灯盏细辛注射液对动脉硬化家兔脂代谢、内皮功能及MMP-9/TIMP-1表达的影响 [8]The preliminary evidence on the association of the gut microbiota with stroke risk stratification in South Chinese population [9]Breviscapine Alleviates Nonalcoholic Steatohepatitis by Inhibiting TGF-β-activated Kinase 1-dependent Signaling. [10]Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD.