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FOXO signaling pathway in skeletal muscle atrophy

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机构： [1]Department of Orthopaedics, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China. [2]Department of Sports Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China [3]Guangxi University of Chinese Medicine, Nanning, Guangxi, China.

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Skeletal muscle atrophy is the consequence of protein degradation exceeding protein synthesis due to disease, aging and physical inactivity. Patients with skeletal muscle atrophy have decreased muscle mass and fiber cross-sectional area, thereby suffering reduced survival quality and motor function. The forkhead box O (FOXO) signaling pathway plays an important role in the pathogenesis of skeletal muscle atrophy by regulating E3 ubiquitin ligases and some autophagy factors. However, the mechanism of FOXO signaling pathway leading to skeletal muscle atrophy is still unclear and needs to be further explored. The development of treatment strategies for skeletal muscle atrophy has been a thorny clinical problem. FOXO-targeted therapy to treat skeletal muscle atrophy is a promising approach, and an increasing number of relevant studies have been reported. In this paper, we reviewed the mechanism and therapeutic targets of the FOXO signaling pathway mediating skeletal muscle atrophy, and provided some new ideas for the clinical treatment of this condition.Copyright © 2022. Published by Elsevier Inc.

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出版当年[2021]版：

大类 | 2 区

医学

小类 | 2 区病理学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区病理学

第一作者：

第一作者机构： [1]Department of Orthopaedics, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

通讯作者：

通讯机构： [1]Department of Orthopaedics, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China. [2]Department of Sports Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China [3]Guangxi University of Chinese Medicine, Nanning, Guangxi, China. [*1]Department of Sports Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, China [*2]Department of Orthopaedics, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

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