机构：[1]Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, China南方医科大学珠江医院[2]Department of Nephrology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China[3]Syndrome Laboratory of Integrated Chinese and Western Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China[4]Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, Guangzhou, China[5]School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning, China
To identify bioactive metabolites from the fruiting body of Morchella sextelata, fourteen metabolites (1-14) including one undescribed morchesexten A (1) were isolated. Their structures including absolute configurations were assigned on the basis of spectroscopic data and quantum chemical computational methods. Furthermore, the anti-inflammatory and antioxidant activities of the isolated compounds were evaluated. Compounds 10-12 showed inhibitory effects on nitric oxide (NO) production with IC50 values of 15.2 +/- 2.7, 10.2 +/- 1.9 and 35.3 +/- 10.5 mu M, respectively. Compounds 7 and 9 exhibited strong antioxidant effect with IC50 values of 6.7 +/- 0.4 and 7.3 +/- 0.8 mu M compared with Vit C (IC50 15.4 +/- 0.2 mu M).
基金：
Talent Fund of Southern Medical University [G620292014]; Natural Science Foundation of Guangdong Province [2020A1515110093]; National Natural Science Foundation of China [82104039, 81460528, 21762010]; Science and Technical Plan of Guangzhou, Guangdong, China [202102011130280005]
第一作者机构：[1]Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, China[3]Syndrome Laboratory of Integrated Chinese and Western Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, China[2]Department of Nephrology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China[3]Syndrome Laboratory of Integrated Chinese and Western Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China[4]Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, Guangzhou, China
推荐引用方式(GB/T 7714)：
Li De-Xian,Cheng Xia,Ma Fo-Pei,et al.Identification of metabolites from edible mushroom Morchella sextelata and their biological evaluation[J].NATURAL PRODUCT RESEARCH.2023,37(11):1774-1781.doi:10.1080/14786419.2022.2119389.
APA：
Li, De-Xian,Cheng, Xia,Ma, Fo-Pei,Chen, Jie-Yu,Chen, Yi-Ping...&Luo, Qi.(2023).Identification of metabolites from edible mushroom Morchella sextelata and their biological evaluation.NATURAL PRODUCT RESEARCH,37,(11)
MLA：
Li, De-Xian,et al."Identification of metabolites from edible mushroom Morchella sextelata and their biological evaluation".NATURAL PRODUCT RESEARCH 37..11(2023):1774-1781
