机构：[1]Department of Nephrology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.[2]Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.[3]Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, China.[4]Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.[5]Neurosurgery Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Aspertaichunol A (1), a polyketide with a novel scaffold, was isolated from the medicinal insect (Periplaneta americana)-derived endophytic Aspergillus taichungensis SMU01. Its structure was assigned on the basis of spectroscopic data and quantum chemical computational methods. Notably, 1 possesses an uncommon tricyclo[6.2.0.02,6]decane motif and an unusual bridgehead double bond (anti-Bredt system). A plausible biosynthetic pathway, involving a key intramolecular [2+2] cycloaddition and a reductive cyclization, is postulated. Finally, the immunomodulatory activity of 1 at 20 nM was evaluated by promoting Th9 cell differentiation from naive CD4+CD62L+ T cells.
基金：
the Talent Fund of Southern Medical University
(G620292014), the Natural Science Foundation of Guangdong
Province (2020A1515110093 and 2021A1515012540),
the National Natural Science Foundation of China (82104039
and 8217101976), and the Science and Technical Plan of
Guangzhou, Guangdong, China (202102020828).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|1 区化学
小类|1 区有机化学
最新[2025]版：
大类|1 区化学
小类|1 区有机化学
第一作者：
第一作者机构：[1]Department of Nephrology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Nephrology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.[2]Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
推荐引用方式(GB/T 7714)：
Cheng Xia,Ma Fo-Pei,Yan Yong-Ming,et al.Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01[J].Organic letters.2022,doi:10.1021/acs.orglett.2c02978.
APA：
Cheng Xia,Ma Fo-Pei,Yan Yong-Ming,Zhao Wen-Li,Shi Jin...&Luo Qi.(2022).Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01.Organic letters,,
MLA：
Cheng Xia,et al."Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01".Organic letters .(2022)
化学