Tumour microenvironment has been linked with immunotherapy response in gastric cancer. Here, the authors use CT-based radiomics to predict neutrophils-to-lymphocyte ratio and response to immunotherapy. The tumor immune microenvironment (TIME) is associated with tumor prognosis and immunotherapy response. Here we develop and validate a CT-based radiomics score (RS) using 2272 gastric cancer (GC) patients to investigate the relationship between the radiomics imaging biomarker and the neutrophil-to-lymphocyte ratio (NLR) in the TIME, including its correlation with prognosis and immunotherapy response in advanced GC. The RS achieves an AUC of 0.795-0.861 in predicting the NLR in the TIME. Notably, the radiomics imaging biomarker is indistinguishable from the IHC-derived NLR status in predicting DFS and OS in each cohort (HR range: 1.694-3.394, P < 0.001). We find the objective responses of a cohort of anti-PD-1 immunotherapy patients is significantly higher in the low-RS group (60.9% and 42.9%) than in the high-RS group (8.1% and 14.3%). The radiomics imaging biomarker is a noninvasive method to evaluate TIME, and may correlate with prognosis and anti PD-1 immunotherapy response in GC patients.
基金：
Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer [2020B121201004]; Key-Area Research and Development Program of Guangdong Province [2021B0101420005]; Guangdong Provincial Major Talents Project [2019JC05Y361]; National Natural Science Foundation of China [82172960, 81872013, 82102156]; Natural Science Foundation of Guangdong Province [2019A1515011445]; Guangzhou Citizen Health Science and Technology Research Project [201903010072]; Outstanding Youth Development Scheme of Nanfang Hospital, Southern Medical University [2018J007]; Director's Foundation of Nanfang Hospital, Southern Medical University [2020Z007]
第一作者机构：[1]Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg, Guangzhou 510515, Guangdong, Peoples R China[2]Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestina, Guangzhou 510515, Guangdong, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg, Guangzhou 510515, Guangdong, Peoples R China[2]Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestina, Guangzhou 510515, Guangdong, Peoples R China[3]Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Dept Gastrointestinal Surg, Affiliated Hosp 2, Dade Rd 111, Guangzhou 510120, Peoples R China[8]Sun Yat Sen Univ, Dept Gastr Surg, Canc Ctr, 651 Dongfeng Rd East, Guangzhou 510060, Peoples R China[9]Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Peoples R China
推荐引用方式(GB/T 7714)：
Huang Weicai,Jiang Yuming,Xiong Wenjun,et al.Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer[J].NATURE COMMUNICATIONS.2022,13(1):doi:10.1038/s41467-022-32816-w.
APA：
Huang, Weicai,Jiang, Yuming,Xiong, Wenjun,Sun, Zepang,Chen, Chuanli...&Li, Guoxin.(2022).Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer.NATURE COMMUNICATIONS,13,(1)
MLA：
Huang, Weicai,et al."Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer".NATURE COMMUNICATIONS 13..1(2022)
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