机构：[1]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China[2]Chronic Airway Disease Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China[3]Huizhou Third People’s Hospital, Guangzhou Medical University, Huizhou, China[4]The First People’s Hospital of Foshan, Foshan, China[5]Shenzhen Second People’s Hospital, Shenzhen, China[6]The Second People’s Hospital of Zhaoqing, Zhaoqing, China[7]The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China[8]The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China中山大学附属第三医院[9]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China广东省中医院[10]Zhongshan Hospital of Sun Yat-sen University, Zhongshan People’s Hospital, Zhongshan, China[11]The Fifth People’s Hospital of Dongguan, Dongguan, China[12]The Third People’s Hospital of Dongguan, Dongguan, China[13]Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China
Background: Chronic cough is a troublesome clinical problem with long-term impacts at the patient level. However, the burden of chronic cough in China is largely unknown. Thus, we performed a multicenter cross-sectional survey on the current status of chronic cough and its impact on quality of life in Guangdong, south China. Methods: Using a standardized questionnaire, we extracted and analyzed the relevant data on demographics, number of visits to a doctor, previous diagnosis, previous medications used and initial diagnosis. Cough-specific quality of life was measured by the Mandarin Chinese version of the Leicester Cough Questionnaire (LCQ-MC). Results: Of 933 patients from 13 tertiary medical centers in Guangdong, 52.2% were female, the median age was 40.0 [interquartile range (IQR), 31.0-52.0] years, and the median duration of chronic cough was 6.0 (IQR, 3.0-24.0) months. Over half (n=452, 54.0%) of the patients had visited physicians & GE;3 times for cough. In terms of previous diagnosis, bronchitis (n=432, 46.5%) had been most frequently diagnosed, followed by pharyngitis (n=246, 26.5%) and asthmatic cough (n=98, 10.5%). A majority of patients with chronic cough had used antitussive agents (n=539, 58.5%), antibiotics (n=374, 40.6%) and traditional Chinese medicine (TCM) (n=294, 31.9%). Among the three subscales of the LCQ-MC, we observed lower scores in the mental health domain than in the physical and social domains (both P < 0.001). Additionally, lower LCQ-MC scores were found in females and patients who saw the doctor > 3 times for both the total and three subscale scores (all P < 0.05). Conclusions: Misdiagnosis and inappropriate treatment are prevalent in patients with chronic cough and lead to considerable antibiotic abuse. Chronic cough markedly affects suffers' quality of life, especially for women.
基金：
Key-Area Research and Development Program of Guangzhou Province [2019B020227006]; Incubative Project for Innovation Team of GMU [2017-159]
第一作者机构：[1]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China[*1]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd., Guangzhou 510120, China.
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China[*1]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd., Guangzhou 510120, China.
推荐引用方式(GB/T 7714)：
Lai Kefang,Huang Lianrong,Zhao Haijin,et al.A multicenter survey on the current status of chronic cough and its impact on quality of life in Guangdong, China[J].JOURNAL OF THORACIC DISEASE.2022,14(9):3624-3632.doi:10.21037/jtd-21-1737.
APA：
Lai, Kefang,Huang, Lianrong,Zhao, Haijin,Wu, Feng,Zhen, Guocui...&Jiang, Yong.(2022).A multicenter survey on the current status of chronic cough and its impact on quality of life in Guangdong, China.JOURNAL OF THORACIC DISEASE,14,(9)
MLA：
Lai, Kefang,et al."A multicenter survey on the current status of chronic cough and its impact on quality of life in Guangdong, China".JOURNAL OF THORACIC DISEASE 14..9(2022):3624-3632
