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Andrographolide contributes to spinal cord injury repair via inhibition of apoptosis, oxidative stress and inflammation

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Li Zhen[1,2,3] * ; Li Zehui[1,2,3] * ; Chen Zhenyue[4,3] ; Sun He[1,2,3] ; Yuan Zhagen[2] ; Wang Xiaochao[1,2,3] ; Wei Jinqiang[1,2,3] ; Cao Xuewei[2] ; Zheng Decai[2] ;
机构： [1]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [2]Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [3]Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [4]The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
出处：
DOI： 10.3389/fphar.2022.949502
ISSN：

关键词： andrographolide spinal cord injury apoptosis oxidative stress inflammation

摘要：
Background: Spinal cord injury (SCI) is a common disorder of the central nervous system with considerable socio-economic burden. Andrographolide (Andro), the main active component of Andrographis paniculata, has exhibited neuroprotective effects in different models of neurological diseases. The aim of this study was to evaluate the neuroprotective effects of Andro against SCI and explore the related mechanisms. Methods: SCI was induced in rats by the Allen method, and the modeled animals were randomly divided into sham-operated, SCI, SCI + normal saline (NS) and SCI + Andro groups. The rats were injected intraperitoneally with Andro (1 mg/kg) or the same volume of NS starting day one after the establishment of the SCI model for 28 consecutive days. Post-SCI tissue repair and functional recovery were evaluated by measuring the spinal cord water content, footprint tests, Basso-Beattie-Bresnahan (BBB) scores, hematoxylin-eosin (HE) staining and Nissl staining. Apoptosis, oxidative stress and inflammation, as well as axonal regeneration and remyelination were analyzed using suitable markers. The in vitro model of SCI was established by treating cortical neurons with H2O2. The effects of Andro on apoptosis, oxidative stress and inflammation were evaluated as indicated. Results: Andro treatment significantly improved tissue repair and functional recovery after SCI by reducing apoptosis, oxidative stress and inflammation through the nuclear factor E2-related factor 2/heme oxygenase-1 (Nrf-2/HO-1) and nuclear factor-kappa B (NF-κB) signaling pathways. Furthermore, Andro treatment promoted M2 polarization of the microglial cells and contributed to axonal regeneration and remyelination to improve functional recovery after SCI. In addition, Andro also attenuated apoptosis, oxidative stress and inflammation in H2O2-stimulated cortical neurons in vitro. Conclusion: Andro treatment alleviated SCI by reducing apoptosis, oxidative stress and inflammation in the injured tissues and cortical neurons, and promoted axonal regeneration and remyelination for functional recovery.Copyright © 2022 Li, Li, Chen, Sun, Yuan, Wang, Wei, Cao and Zheng.

基金：
This study was supported by a grant from the Construction project of the inheritance studio of Xianzhang Huang, a famous Chinese medicine doctor in Guangdong Province (NO.20200741, 20212148, and 20220037) and Guangdong Provincial Hospital of Traditional Chinese Medicine and the School of Biomedicine, Chinese University of Hong Kong School of Medicine, Basic Clinical Collaborative Innovation Project (NO.YN2018HK04).
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 药学
JCR分区：
出版当年[2020]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [2]Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [3]Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Zhen,Li Zehui,Chen Zhenyue,et al.Andrographolide contributes to spinal cord injury repair via inhibition of apoptosis, oxidative stress and inflammation[J].FRONTIERS IN PHARMACOLOGY.2022,13:doi:10.3389/fphar.2022.949502.
APA：
Li Zhen,Li Zehui,Chen Zhenyue,Sun He,Yuan Zhagen...&Zheng Decai.(2022).Andrographolide contributes to spinal cord injury repair via inhibition of apoptosis, oxidative stress and inflammation.FRONTIERS IN PHARMACOLOGY,13,
MLA：
Li Zhen,et al."Andrographolide contributes to spinal cord injury repair via inhibition of apoptosis, oxidative stress and inflammation".FRONTIERS IN PHARMACOLOGY 13.(2022)

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