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Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial

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机构： [1]Center for Prevention and Cure of Breast Diseases, Maternal and Child Health Hospital, Haidian District, Beijing 100080, China [2]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital and Institute, Beijing, China [3]Breast Department, Obstetrics and Gynecology Hospital, Kaifeng, Henan Province, China [4]Breast Department, Guangzhou Women and Children’s Medical Center, Guanzhou, Guangdong Province, China [5]Breast Department, Taiyuan Maternity and Child Health Care Hospital, Taiyuan, Jiangxi Province, China [6]Breast Department, Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, Zhejiang Province, China [7]Breast Department, Changde First Hospital of Traditional Chinese Medicine, Changde, Hunan Province, China [8]Breast Department, Sanya City Womenfolk and Infant Health Care Hospital, Sanya, Hainan Province, China [9]Breast Department, Jilin Women and Children Health Hospital, Changchun, Jilin Province, China [10]Breast Department, Beijing University of Chinese Medicine Third Afliated Hospital, Beijing, China [11]Breast Department, Anyang Maternal and Child Health Care Hospital, Anyang, Henan Province, China [12]Breast Department, Shenzhen Maternity and Child Health Care Hospital, Shenzhen, Guangdong Province, China [13]Breast Department, Jiangyin People’s Hospital, Jiangyin, Jiangsu Province, China

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Although oral probiotics can improve breast microecology and alleviate the inflammatory response, there are no data regarding cases with existing abscesses. We aimed to investigate the effect of Lactobacillus fermentum CECT5716 during needle aspiration in patients with lactational breast abscesses. Patients (aged 20-41 years) with lactational single-cavity breast abscesses (diameter 3-6 cm) from 12 hospitals were randomly assigned to the experimental (n = 51) and control groups (n = 50). Outcome measures included the abscess cure rate on treatment day-5, delactation rate, relieving pain rate, and number of needle aspirations until day-28. The experimental group's 5-day cure rate (43.1%) was significantly higher (p < 0.05). Breastfeeding continuation on day-5 did not differ significantly (experimental group: 88.2%, control group: 96.0%, p = 0.269). In the experimental and control groups, 19.6% and 14.0% of patients experienced moderate to severe pain on day-5, respectively, with no statistically significant differences (p = 0.451). Four patients in each group developed diarrhea, with adverse reaction rates of 7.84% and 8.0%, respectively. No adverse reactions were reported in the infants. L. fermentum can shorten the healing time in patients with lactational breast abscesses.Trial registration This study was registered in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn ), registration number: ChiCTR2000032682, registration date: 6/May/ 2020; first entry date: 11/May/2020.© 2022. The Author(s).

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出版当年[2021]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

最新[2025]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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第一作者机构： [1]Center for Prevention and Cure of Breast Diseases, Maternal and Child Health Hospital, Haidian District, Beijing 100080, China

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