The high-affinity IgE receptor, Fc epsilon RI, plays a key role in the antigen-induced mast cell activation. Regulations for Fc epsilon RI are not yet well understood. TAFA4 is a molecule derived from neuron tissues, and has immune regulation functions. This study aims to clarify the role of TAFA4 in the regulation of Fc epsilon RI expression in mast cells. Nasal secretions were collected from patients with allergic rhinitis (AR) and healthy control (HC) subjects. TAFA4 levels of nasal secretions were evaluated by ELISA. A mouse model AR was developed using ovalbumin as the specific antigen. Negative correlation between TAFA4 and tryptase levels in nasal secretions was observed. TAFA4 could suppress the antigen-related mast cell activation. TAFA4 modulated the transcription of Fcer1g (Fc epsilon RI gamma gene) in mast cells. Signals from the TAFA4-PTEN-PU.1 axis restricted Fc epsilon RI expression in mast cells. Administration of TAFA4 attenuated experimental AR. TAFA4 suppressed the expression of Fc epsilon RI in mast cells of airway tissues. TAFA4 can down regulate the expression of Fc epsilon RI in mast cells to suppress experimental AR. The data suggest that TAFA4 has translation potential to be developed as an anti-allergy therapy. TAFA4 suppressed the expression of FceRI in mast cells of airway tissues. Signals from the TAFA4-PTEN-PU.1 axis restricted FceRI expression in mast cells. Administration of TAFA4 attenuated experimental AR.
基金：
National Nature and Science Foundation of China [32090052, 32000655]; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases [2019B030301009]; Joint Youth Fund for Basic and Applied Basic Research of Guangdong Province [2019A1515111095]; International Cooperative Research Project of Shenzhen Collaborative Innovation Program [GJHZ20190821173801659]; Shenzhen science, technology and innovation committee [KQTD20170331145453160]
第一作者机构：[1]Longgang Tradit Chinese Med Hosp, Shenzhen, Peoples R China[2]Beijing Univ, Chinese Med Shenzhen Hosp, Shenzhen, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[3]Shenzhen Univ, Affiliated Hosp 3, Dept Respirol & Allergy, Shenzhen, Peoples R China[4]Guangdong Prov Reg Dis Key Lab, Shenzhen, Peoples R China[5]Guangdong Prov Reg Dis Key Lab, Inst Allergy & Immunol, State Key Lab Resp Dis Allergy Div, Shenzhen, Chin, Myanmar[*1]Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China[*2]Room A7-509, 1066 Xueyuan Blvd, Shenzhen, China
推荐引用方式(GB/T 7714)：
Zhou Caijie,Li Meihua,Liu Yu,et al.Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of Fc epsilon RI in mast cells[J].CLINICAL AND EXPERIMENTAL IMMUNOLOGY.2023,211(1):15-22.doi:10.1093/cei/uxac097.
APA：
Zhou, Caijie,Li, Meihua,Liu, Yu,Wang, Xinxin,Zhang, Shuang...&Yang, Pingchang.(2023).Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of Fc epsilon RI in mast cells.CLINICAL AND EXPERIMENTAL IMMUNOLOGY,211,(1)
MLA：
Zhou, Caijie,et al."Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of Fc epsilon RI in mast cells".CLINICAL AND EXPERIMENTAL IMMUNOLOGY 211..1(2023):15-22
