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A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway

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收录情况： ◇ SCIE

作者：
Wang Jing[1] * ; Xie Jingjing[2,3] * ; Chen Haixia[4,5] * ; Qiu Xia[2,3] ; Cui Hai[6] ; Liu Yijiang[6] ; Sahu Sunil Kumar[4] ; Fang Dongming[4] ; Li Tengyan[7] ; Wang Mei[4] ; Chen Yewen[4,5] ; Liu Huan[4,8] ; Zhang Jianyong[2,3] ; Wang Binbin[7] ;
机构： [1]Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 10069, China. [2]Department of Rheumatism, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, China. [3]The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China. [4]State Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen 518120, China. [5]College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China. [6]School of Traditional Chinese Medicine, Capital Medical University, Beijing 10069, China. [7]Center for Genetics, National Research Institute for Family Planning, Beijing, China. [8]Department of Biology, University of Copenhagen, Copenhagen, Denmark.
出处：
DOI： 10.1038/s42003-022-04229-4
ISSN：

摘要：
Cremastra appendiculata (D. Don) Makino is a rare terrestrial orchid with a high market value as an ornamental and Chinese traditional medicinal herb with a wide range of pharmacological properties. The pseudobulbs of C. appendiculata are one of the primary sources of the famous traditional Chinese medicine "Shancigu", which has been clinically used for treating many diseases, especially, as the main component to treat gout. The lack of genetic research and genome data restricts the modern development and clinical use of C. appendiculata. Here, we report a 2.3 Gb chromosome-level genome of C. appendiculata. We identify a series of candidates of 35 candidate genes responsible for colchicine biosynthesis, among which O-methyltransferase (OMT) gene exhibits an important role in colchicine biosynthesis. Co-expression analysis reveal purple and green-yellow module have close relationships with pseudobulb parts and comprise most of the colchicine pathway genes. Overall, our genome data and the candidate genes reported here set the foundation to decipher the colchicine biosynthesis pathways in medicinal plants.© 2022. The Author(s).

基金：
This work was supported by the Science and Technology Planning Project of Shenzhen Municipality (JCYJ20170817094922513 and JCYJ20210324120405016), the Major Science and Technology Projects of Yunnan Province (Digi- talization, development and application of biotic resource, No. 860 202002AA100007, H.L.),, the Sanming Project of Medicine in Shenzhen (Rheumatism team of Prof. Jiang Quan from Guang’anmen Hospital, China Academy of Chinese Medical Sciences (Grant no. SZSM201612080) and the National Key R&D Program of China (2019YFC1711000). This work is part of the 10KP project. We sincerely thank the support provided by China National GeneBank.
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 生物学
小类 | 1 区 生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生物学
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出版当年[2020]版：
Q1 BIOLOGY
最新[2023]版：
Q1 BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 10069, China.
共同第一作者：
通讯作者：
通讯机构： [2]Department of Rheumatism, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, China. [3]The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China. [4]State Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen 518120, China. [8]Department of Biology, University of Copenhagen, Copenhagen, Denmark.
推荐引用方式(GB/T 7714)：
Wang Jing,Xie Jingjing,Chen Haixia,et al.A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway[J].COMMUNICATIONS BIOLOGY.2022,5(1):doi:10.1038/s42003-022-04229-4.
APA：
Wang Jing,Xie Jingjing,Chen Haixia,Qiu Xia,Cui Hai...&Wang Binbin.(2022).A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway.COMMUNICATIONS BIOLOGY,5,(1)
MLA：
Wang Jing,et al."A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway".COMMUNICATIONS BIOLOGY 5..1(2022)

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