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Preserved Ratio Impaired Spirometry in Relation to Cardiovascular Outcomes: A Large Prospective Cohort Study

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zheng Jiazhen[1,2,3] * ; Zhou Rui[3] ; Zhang Yingchai[4] ; Su Kelei[5] ; Chen Haowen[3,6] ; Li Furong[7] ; Hukportie Daniel Nyarko[3] ; Niu Fangbing[8] ; Yiu Kaihang[9,10,*1,*2] ; Wu Xianbo[3,*3] ;
机构： [1]Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, Guangdong, China. [2]Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China [3]Department of Epidemiology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, China. [4]Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong SAR, China. [5]Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu, China. [6]Institute of Applied Health Research, University of Birmingham, Birmingham, UK. [7]School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong China. [8]Department of tuberculosis, Hebei Chest Hospital, Hebei, China. [9]Cardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen Hospital, Shenzhen city, Guangdong province, China. [10]Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Island, Hong Kong, China.
出处：
DOI： 10.1016/j.chest.2022.11.003
ISSN：

关键词： PRISm lung function risk cardiovascular events epidemiology

摘要：
Preserved ratio impaired spirometry (PRISm) is a heterogeneous condition characterized by a normal forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio with underlying impairment of pulmonary function. Data relating to the association of baseline and trajectories of PRISm with diverse cardiovascular outcomes is sparse.How do baseline and trajectories of PRISm impact subsequent cardiovascular events?In the UK Biobank cohort study, we included cardiovascular disease (CVD) free participants with spirometry (FEV1 and FVC values) at baseline (2006-2010). Participants with baseline spirometry and follow-up spirometry (2014-2020) were included in the lung function trajectory analysis. Cox proportional hazards multivariable regression was performed to evaluate the outcomes of major adverse cardiovascular events (MACE), incident myocardial infarction (MI), stroke, heart failure (HF), and CVD mortality in association with lung function.For baseline analysis (329,954 participants), the multivariable adjusted hazard ratios (HR) for participants had PRISm (vs. normal spirometry) were 1.26 (95% confidence interval (CI) 1.17-1.35) for MACE, 1.12 (1.01-1.25) for MI, 1.88 (1.72-2.05) for HF, 1.26 (1.13-1.40) for stroke, and 1.55 (1.37-1.76) for CVD mortality, respectively. A total of 22,781 participants had a follow-up spirometry after average of 8.9 years. Trajectory analysis showed that persistent PRISm (HR 1.96; 95% CI 1.24-3.09) and airflow obstruction (HR 1.43; 95% CI 1.00-2.04) was associated with a higher incidence of MACE versus consistently normal lung function. Compared with persistent PRISm, changing from PRISm to normal spirometry was associated with a lower incidence of MACE (HR 0.42; 95% CI 0.19-0.99).Individuals with baseline or persistent PRISm were at a higher risk of diverse cardiovascular outcomes even after adjusting for a wide range of confounding factors. However, individuals who transitioned from PRISm to normal had a similar cardiovascular risk as those with normal lung function.Copyright © 2022. Published by Elsevier Inc.

基金：
This study was supported by the Sanming Project of Medicine in Shenzhen, China (SZSM201911020), HKU-SZH Fund for Shenzhen Key Medical Discipline (SZXK2020081), National Natural Science Foundation of China (82173607), the Guangdong Basic and Applied Basic Research Foundation (2021A1515011684), Open Project of the Guangdong Provincial Key Laboratory of Tropical Disease Research (2020B1212060042) and Guangzhou Science and Technology Project (202102080597).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 2 区 呼吸系统 2 区 危重病医学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 呼吸系统 2 区 危重病医学
JCR分区：
出版当年[2021]版：
Q1 CRITICAL CARE MEDICINE Q1 RESPIRATORY SYSTEM
最新[2023]版：
Q1 CRITICAL CARE MEDICINE Q1 RESPIRATORY SYSTEM

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, Guangdong, China. [2]Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China [3]Department of Epidemiology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, China.
通讯作者：
通讯机构： [3]Department of Epidemiology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, China. [9]Cardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen Hospital, Shenzhen city, Guangdong province, China. [10]Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Island, Hong Kong, China. [*1]Cardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen Hospital, No. 1 Haiyuan 1st Rd, Futian district, Shenzhen city, Guangdong province, 518009, China. [*2]Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pok Fu Lam Rd 102. Hong Kong Island, Hong Kong, 999077, China. [*3]Department of Epidemiology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, Guangdong 510515, China
推荐引用方式(GB/T 7714)：
Zheng Jiazhen,Zhou Rui,Zhang Yingchai,et al.Preserved Ratio Impaired Spirometry in Relation to Cardiovascular Outcomes: A Large Prospective Cohort Study[J].CHEST.2023,163(3):610-623.doi:10.1016/j.chest.2022.11.003.
APA：
Zheng Jiazhen,Zhou Rui,Zhang Yingchai,Su Kelei,Chen Haowen...&Wu Xianbo.(2023).Preserved Ratio Impaired Spirometry in Relation to Cardiovascular Outcomes: A Large Prospective Cohort Study.CHEST,163,(3)
MLA：
Zheng Jiazhen,et al."Preserved Ratio Impaired Spirometry in Relation to Cardiovascular Outcomes: A Large Prospective Cohort Study".CHEST 163..3(2023):610-623

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