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Stiffness-Transformable Nanoplatforms Responsive to the Tumor Microenvironment for Enhanced Tumor Therapeutic Efficacy

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机构: [1]Nanjing University of Posts and Telecommunications, Institute of Advanced Materials, CHINA. [2]Affiliated Hospital of Nanjing University of Chinese Medicine: Jiangsu Province Academy of Traditional Chinese Medicine, Department of Radiology, CHINA. [3]Southern Medical University, Guangdong Key Laboratory of New Drug Screening, CHINA. [4]Nanjing Medical University affiliated Nanjing Hospital: Nanjing First Hospital, Department of Ultrasound Diagnostics, CHINA. [5]RMIT University, School of Engineering, CHINA. [6]Nanjing University, Collaborative Innovation Center of Advanced Microstructures, CHINA. [7]Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Collaborative Innovation Center of Advanced Microstructures, CHINA. [8]Nanjing University of Posts and Telecommunications, Materials Science and Engineering, 9 Wenyuan Road, 210003, Nanjing, CHINA.
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Herein, we report, for the first time, a unique stiffness-transformable manganese oxide hybridized mesoporous organosilica nanoplatform (MMON) for enhancing tumor therapeutic efficacy. The prepared MMONs had a quasi-spherical morphology and were completely transformed into soft bowl-like nanocapsules in the simulated tumor microenvironment through the breakage of Mn-O bonds, which decreased their Young's modulus from 165.7 to 84.5 MPa. Due to their unique stiffness transformation properties, the MMONs had reduced macrophage internalization, improved tumor cell uptake, and enhanced penetration of multicellular spheroids. In addition, in vivo experiments showed that the MMONs displayed a 3.79- and 2.90-fold decrease in non-specific liver distribution and a 2.87- and 1.83-fold increase in tumor accumulation compared to their soft and stiff counterparts, respectively. Furthermore, chlorin e6 (Ce6) modified MMONs had significantly improved photodynamic therapeutic effect.© 2022 Wiley-VCH GmbH.

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大类 | 1 区 化学
小类 | 1 区 化学综合
最新[2025]版:
大类 | 1 区 化学
小类 | 1 区 化学:综合
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第一作者机构: [1]Nanjing University of Posts and Telecommunications, Institute of Advanced Materials, CHINA.
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