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Research progress on effects of traditional Chinese medicine on myocardial ischemia-reperfusion injury: A review

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机构： [1]Zhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, China. [2]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. [3]Department of Physiology, University of Toronto, Toronto, ON, Canada. [4]College of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, China. [5]College of Pharmacy, Southern Medical University, Guangzhou, Guangdong, China. [6]University of Chinese Academy of Sciences, Beijing, China. [7]College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning, China. [8]Department of Cardiology, Zhongshan Hospital Affiliated with Guangzhou University of Chinese Medicine (Zhongshan Hospital of Traditional Chinese Medicine), Zhongshan, Guangdong, China. [9]Guangzhou University of Chinese Medicine, Guangzhou, China. [10]College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang, China.

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Ischemic heart disease (IHD) is a high-risk disease in the middle-aged and elderly population. The ischemic heart may be further damaged after reperfusion therapy with percutaneous coronary intervention (PCI) and other methods, namely, myocardial ischemia-reperfusion injury (MIRI), which further affects revascularization and hinders patient rehabilitation. Therefore, the investigation of new therapies against MIRI has drawn great global attention. Within the long history of the prevention and treatment of MIRI, traditional Chinese medicine (TCM) has increasingly been recognized by the scientific community for its multi-component and multi-target effects. These multi-target effects provide a conspicuous advantage to the anti-MIRI of TCM to overcome the shortcomings of single-component drugs, thereby pointing toward a novel avenue for the treatment of MIRI. However, very few reviews have summarized the currently available anti-MIRI of TCM. Therefore, a systematic data mining of TCM for protecting against MIRI will certainly accelerate the processes of drug discovery and help to identify safe candidates with synergistic formulations. The present review aims to describe TCM-based research in MIRI treatment through electronic retrieval of articles, patents, and ethnopharmacology documents. This review reported the progress of research on the active ingredients, efficacy, and underlying mechanism of anti-MIRI in TCM and TCM formulas, provided scientific support to the clinical use of TCM in the treatment of MIRI, and revealed the corresponding clinical significance and development prospects of TCM in treating MIRI.Copyright © 2022 Xing, Long, Zhang, Fu, Huang, Chaurembo, Chanda, Xu, Shu, Lin, Yang and Lin.

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出版当年[2021]版：

大类 | 2 区

医学

小类 | 2 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药学

第一作者：

第一作者机构： [1]Zhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, China. [2]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

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通讯作者：

通讯机构： [1]Zhongshan Institute for Drug Discovery, SIMM CAS, Zhongshan, Guangdong, China. [2]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. [6]University of Chinese Academy of Sciences, Beijing, China. [10]College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang, China.

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