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Oxymatrine ameliorates white matter injury by modulating gut microbiota after intracerebral hemorrhage in mice

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收录情况： ◇ SCIE

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机构： [1]Clinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China. [2]Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou, China. [3]Laboratory Animal Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China. [4]Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. [5]Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, China. [6]Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Centre for Brain Science and BrainInspired Intelligence, Southern Medical University, Guangzhou, China.

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White matter injury (WMI) significantly affects neurobehavioral recovery in intracerebral hemorrhage (ICH) patients. Gut dysbiosis plays an important role in the pathogenesis of neurological disorders. Oxymatrine (OMT) has therapeutic effects on inflammation-mediated diseases. Whether OMT exerts therapeutic effects on WMI after ICH and the role of gut microbiota involved in this process is largely unknown.Neurological deficits, WMI, gut microbial composition, intestinal barrier function, and systemic inflammation were investigated after ICH. Fecal microbiota transplantation (FMT) was performed to elucidate the role of gut microbiota in the pathogenesis of ICH.OMT promoted long-term neurological function recovery and ameliorated WMI in the peri-hematoma region and distal corticospinal tract (CST) region after ICH. ICH induced significant and persistent gut dysbiosis, which was obviously regulated by OMT. In addition, OMT alleviated intestinal barrier dysfunction and systemic inflammation. Correlation analysis revealed that gut microbiota alteration was significantly correlated with inflammation, intestinal barrier permeability, and neurological deficits after ICH. Moreover, OMT-induced gut microbiota alteration could confer protection against neurological deficits and intestinal barrier disruption.Our study demonstrates that OMT ameliorates ICH-induced WMI and neurological deficits by modulating gut microbiota.© 2022 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.

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出版当年[2021]版：

大类 | 2 区医学

小类 | 2 区神经科学 2 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药学 3 区神经科学

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出版当年[2020]版：

Q1 PHARMACOLOGY & PHARMACY Q2 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.8 最新[2023版] 5.9 最新五年平均 5.243 出版当年[2020版] 4.977 出版当年五年平均 4.074 出版前一年[2019版] 7.035 出版后一年[2021版]

第一作者：

第一作者机构： [1]Clinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China. [2]Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

通讯作者：

通讯机构： [1]Clinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China. [2]Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou, China. [6]Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Centre for Brain Science and BrainInspired Intelligence, Southern Medical University, Guangzhou, China. [*1]Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, 253# Gongye Road, Guangzhou 510280, China.

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