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Quantitative infrapatellar fat pad signal intensity alteration as an imaging biomarker of knee osteoarthritis progression

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机构： [1]Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China [2]Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia [3]Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China [4]Department of Rheumatology and Immunology, The Second Hospital of Anhui Medical University, Hefei, Anhui, China [5]School of Mathematics and Information Science, Nanjing Normal University of Special Education, Nanjing, Jiangsu, China [6]Department of Public Health and General Medicine, School of Life Sciences, Anhui University of Chinese Medicine, Hefei, Anhui, China [7]Department of Health Management, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China [8]Clinical Research Centre, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China [9]Department of Rheumatology and Clinical Immunology, Beijing An Zhen Hospital, Capital Medical University, Beijing, Beijing, China [10]Department of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia

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To determine the association of quantitative infrapatellar fat pad (IPFP) signal intensity alteration with knee osteoarthritis (OA) progression.This study was performed based on the Foundation for the National Institutes of Health OA Biomarkers Consortium study, a nested case-control study consisting of 600 participants. The IPFP signal intensity alterations were quantitatively measured at baseline, 12 months and 24 months. The associations of baseline and time-integrated values over 12 and 24 months of IPFP signal intensity measures with knee OA progression over 48 months were evaluated with adjustment for baseline confounders.The baseline level of clustering effect of high signal intensity (Clustering factor (H)) was predictive of clinically relevant progression (both radiographic and pain progression) (OR 1.22). The time-integrated values of all IPFP signal intensity measures, except for mean value of IPFP signal intensity (Mean (IPFP)) over 24 months (ORs ranging from 1.23 to 1.39) as well was all except for Mean (IPFP) and mean value of IPFP high signal intensity (Mean (H)) over 12 months (ORs ranging from 1.20 to 1.31), were positively associated with clinically relevant progression. When the associations of quantitative IPFP signal intensity measures with radiographic and pain progression were examined separately, more IPFP signal intensity measures with stronger effect sizes were associated with radiographic progression compared with pain progression.The associations of short-term alteration in quantitative IPFP signal intensity measures with long-term knee OA progression suggest that these measures might serve as efficacy of intervention biomarkers of knee OA.© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区风湿病学

最新[2025]版：

大类 | 2 区

医学

小类 | 2 区风湿病学

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出版当年[2021]版：

Q1 RHEUMATOLOGY

最新[2023]版：

Q1 RHEUMATOLOGY

影响因子： 5.1 最新[2023版] 5 最新五年平均 5.806 出版当年[2021版] 5.266 出版当年五年平均 5.117 出版前一年[2020版] 6.2 出版后一年[2022版]

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第一作者机构： [1]Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China [2]Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia

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通讯作者：

通讯机构： [1]Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China [2]Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia

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