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A Mechanism Exploration for the Yi-Fei-San-Jie Formula against Non-Small-Cell Lung Cancer Based on UPLC-MS/MS, Network Pharmacology, and In Silico Verification

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收录情况： ◇ SCIE

作者：
Hu Leihao[1] * ; He Canfeng[1] ; Mo Aier[2] ; Zhan Xingkai[3] ; Yang Caizhi[1] ; Guo Wei[4] ; Sun Lingling[4] ; Su Weiwei[5] ; Lin Lizhu[4] ;
机构： [1]1School of the First Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [2]Dongguan Hospital of Integrated Chinese and Western Medicine, Dongguan, Guangdong, China [3]School of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [4]Oncology Center, 'e First A(liated Hospital of Guangzhou University of Chinese Medicine, No. 16 Airport Road, Guangzhou, Guangdong 510405, China [5]Guangdong Engineering & Technology Research Center for Quality and E(cacy Reevaluation of Post Market Traditional Chinese Medicine, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou, Guangdong 510275, China
出处：
DOI： 10.1155/2023/3436814
ISSN：

摘要：
Non-small-cell lung cancer (NSCLC) is one of the most prevalent cancers worldwide. A Yi-Fei-San-Jie formula (YFSJF), widely used in NSCLC treatment in south China, has been validated in clinical studies. However, the pharmacological mechanism behind it remains unclear. In this study, 73 compounds were identified using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), with 58 enrolled in network pharmacology. The protein-protein interaction network, functional enrichment analysis, and compound-target-pathway network were constructed using 74 overlapping targets from 58 drugs and NSCLC. YFSJF has many targets and pathways in the fight against NSCLC. PIK3R1, PIK3CA, and AKT1 were identified as key targets, and the PI3K/AKT pathway was identified as the key pathway. According to the Human Protein Atlas (THPA) database and the Kaplan-Meier Online website, the three key targets had varying expression levels in normal and abnormal tissues and were linked to prognosis. Molecular docking and dynamics simulations verified that hub compounds have a strong affinity with three critical targets. This study revealed multiple compounds, targets, and pathways for YFSJF against NSCLC and suggested that YFSJF might inhibit PIK3R1, PIK3CA, and AKT1 to suppress the PI3K/AKT pathway and play its pharmacological role.Copyright © 2023 Leihao Hu et al.

基金：
.is work was supported by the Collaborative Innovation Research and High-Level Team Building of Integrated Chinese and Western Medicine in Diagnosis and Treatment of Malignant Tumors (No. 2021XK09), the Basic .eoretical Research of Chinese Medicine of the Guangzhou University of Chinese Medicine (Jiebang Guashuai Lizhu Lin project, No. Project [2022]-7), the Cooperative Research of High- Level Hospital Project (Lung Cancer) (2019–2022), the National Natural Science Foundation of China (No. 82104647 and No. 81973775), and the Postdoctoral Science Foundation of China (No. 2021M700964). .e authors thank Bullet Edits Limited for the linguistic editing and proofreading of the manuscript.
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出版当年[2022]版：
大类 | 4 区 医学
小类 | 4 区 全科医学与补充医学
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无
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出版当年[2021]版：
Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
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影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版]

第一作者：
第一作者机构： [1]1School of the First Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Leihao,He Canfeng,Mo Aier,et al.A Mechanism Exploration for the Yi-Fei-San-Jie Formula against Non-Small-Cell Lung Cancer Based on UPLC-MS/MS, Network Pharmacology, and In Silico Verification[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2023,2023:doi:10.1155/2023/3436814.
APA：
Hu Leihao,He Canfeng,Mo Aier,Zhan Xingkai,Yang Caizhi...&Lin Lizhu.(2023).A Mechanism Exploration for the Yi-Fei-San-Jie Formula against Non-Small-Cell Lung Cancer Based on UPLC-MS/MS, Network Pharmacology, and In Silico Verification.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2023,
MLA：
Hu Leihao,et al."A Mechanism Exploration for the Yi-Fei-San-Jie Formula against Non-Small-Cell Lung Cancer Based on UPLC-MS/MS, Network Pharmacology, and In Silico Verification".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2023.(2023)

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