机构：[1]Graduate School of Hunan University of Chinese Medicine, Changsha, Hunan, China.[2]Shenzhen Institute of Translational Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Futian District, Shenzhen, Guangdong, China.深圳市第二人民医院深圳医学信息中心[3]School of Big Data and Internet, Shenzhen Technology University, Pingshan District, Shenzhen, Guangdong, China.[4]Hebei Key Laboratory for Chronic Diseases, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China.
The pursuit of easy-to-use, non-invasive and inexpensive diagnostics is an urgent task for clinicians and scientists. Saliva is an important component of body fluid with regular changes of contents under various pathophysiological conditions, and the biomarkers identified from saliva shows high application potentials and values in disease diagnostics. This review introduces the latest developments in saliva research, with an emphasis on the detection and application of salivary biomarkers in cancer detection.Detection of disease-specific biomarkers in saliva samples by existing salivaomic methods can be used to diagnose various human pathological conditions and was introduced in details. This review also covers the saliva collection methods, the analytical techniques as well as the corresponding commercial products, with an aim to describe an holistic process for saliva-based diagnostics.Saliva, as a non-invasive and collectable body fluid, can reflect the pathophysiological changes of the human body to a certain extent. Identification of reliable saliva biomarkers can provide a convenient way for cancer detection in clinical applications.
基金：
The authors acknowledge funding from the National Natural Science Foundation of China (81804154), the Shenzhen High-Level Hospital Construction Fund (4001020), the Shenzhen Science and Technology Innovation Committee Funds (JCYJ20190812171807146), and the Fundamental Research Funds for the Central Universities (JQN2022026).
第一作者机构：[1]Graduate School of Hunan University of Chinese Medicine, Changsha, Hunan, China.[2]Shenzhen Institute of Translational Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Futian District, Shenzhen, Guangdong, China.
通讯作者：
通讯机构：[1]Graduate School of Hunan University of Chinese Medicine, Changsha, Hunan, China.[2]Shenzhen Institute of Translational Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Futian District, Shenzhen, Guangdong, China.
推荐引用方式(GB/T 7714)：
Liu Jieren,Huang Dongna,Cai Yuanzhe,et al.Saliva diagnostics: emerging techniques and biomarkers for salivaomics in cancer detection[J].EXPERT REVIEW OF MOLECULAR DIAGNOSTICS.2022,22(12):1077-1097.doi:10.1080/14737159.2022.2167556.
APA：
Liu Jieren,Huang Dongna,Cai Yuanzhe,Cao Zhihua,Liu Zhiyu...&Wu Zhengzhi.(2022).Saliva diagnostics: emerging techniques and biomarkers for salivaomics in cancer detection.EXPERT REVIEW OF MOLECULAR DIAGNOSTICS,22,(12)
MLA：
Liu Jieren,et al."Saliva diagnostics: emerging techniques and biomarkers for salivaomics in cancer detection".EXPERT REVIEW OF MOLECULAR DIAGNOSTICS 22..12(2022):1077-1097
：