机构：[1]Guangdong Provincial Key Laboratory of Pathogenesis of Heart and Spleen and Prescription Drugs Research, Department of Pharmacology, School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.[2]Department of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
Preeclampsia (PE) is a typical hypertensive disorders of pregnancy (HDP) which can cause substantial morbidity and mortality in both pregnant women and fetuses. The renin-angiotensin system (RAS) genes are the main HDP-causing genes, and Angiotensinogen (AGT) as the initial substrate can directly reflect the activity of the entire RAS. However, the association between AGT SNPs and PE risk has rarely been confirmed. This study was carried out to determine whether AGT SNPs could affect the risk of PE in 228 cases and 358 controls. The genotyping result revealed that the AGT rs7079 TT carrier was related to increased PE risk. Further stratified analysis illustrated that the rs7079 TT genotype significantly increased the PE risk in subgroups of Age < 35, BMI < 25, Albumin (ALB) ≥ 30 and Aspartate aminotransferase (AST) < 30. These findings demonstrated that the rs7079 might be a promising candidate SNP strongly associated with PE susceptibility.
基金：
This work was supported by the National Natural Science Foundation of China [82274130,
82230126, 82171666]; the Major Program of Science and Technology Program of Guangzhou [202103000044];
the Guangzhou Science and Technology Foundation [202102010266]; the Major Basic Research Program of
Guangdong [2021ZDZX2041].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区医学
小类|2 区医学：内科
最新[2025]版：
大类|3 区医学
小类|3 区医学：内科
第一作者：
第一作者机构：[1]Guangdong Provincial Key Laboratory of Pathogenesis of Heart and Spleen and Prescription Drugs Research, Department of Pharmacology, School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
He Dong,Peng Xianglan,Xie Hongkai,et al.Genetic Variations in Angiotensinogen Gene and Risk of Preeclampsia: A Pilot Study[J].Journal of clinical medicine.2023,12(4):doi:10.3390/jcm12041509.
APA：
He Dong,Peng Xianglan,Xie Hongkai,Peng Rui,Li Qixuan...&Chen Yang.(2023).Genetic Variations in Angiotensinogen Gene and Risk of Preeclampsia: A Pilot Study.Journal of clinical medicine,12,(4)
MLA：
He Dong,et al."Genetic Variations in Angiotensinogen Gene and Risk of Preeclampsia: A Pilot Study".Journal of clinical medicine 12..4(2023)
医学