Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity
机构：[1]Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hung Hom, Hong Kong[2]Mental Health Research Center, Hong Kong Polytechnic University, Hung Hom, Hong Kong[3]Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510260, China[4]School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266000, China[5]Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China[6]Interdisciplinary Institute for Personalized Medicine in Brain Disorders, School of Chinese Medicine, Jinan University, Guangzhou 510632, China[7]Departments of Psychiatry & Clinical and Translational Institute of Psychiatric Disorders, First Affiliated Hospital of Jinan University, Guangzhou 510632, China[8]Co-Innovation Center of Neurogeneration, Nantong University, Nantong 226001, China[9]Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, 1090 Vienna, Austria[10]The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong
(1) Background: Adiponectin is an adipocyte-secreted hormone that has antidepressant- and anxiolytic-like effects in preclinical studies. Here, we investigated the antidepressant- and anxiolytic-like effects of sub-chronic treatment with AdipoRon, an adiponectin receptor agonist, and its potential linkage to changes in hippocampal adult neurogenesis and synaptic plasticity. (2) Methods: Different cohorts of wild-type C57BL/6J and CamKIIα-Cre male mice were treated with sub-chronic (7 days) AdipoRon, followed by behavioral, molecular, and electrophysiological experiments. (3) Results: 7-day AdipoRon treatment elicited antidepressant- and anxiolytic-like effects but did not affect hippocampal neurogenesis. AdipoRon treatment reduced hippocampal brain-derived neurotrophic factor (BDNF) levels, neuronal activation in the ventral dentate gyrus, and long-term potentiation of the perforant path. The knockdown of N-methyl-D-aspartate (NMDA) receptor subunits GluN2A and GluN2B in the ventral hippocampus did not affect the antidepressant- and anxiolytic-like effects of AdipoRon. (4) Conclusions: Increasing adiponectin signaling through sub-chronic AdipoRon treatment results in antidepressant- and anxiolytic-like effects independent of changes in hippocampal structural and synaptic function.
基金：
This research was supported by funding awarded to SY Yau by The Hong Kong Research
Grant Council (GRF: 15100018, GRF15104620, GRF15104019, and GRF1510001); the National Natural
Science Foundation of China (Young Investigator Scheme: 81801346); and the Seed fund supported
by the Research Institute of Smart Ageing (RISA), The Hong Kong Polytechnic University, and to
Chen G by the National Natural Science Foundation of China: (82174002).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|3 区工程技术
小类|3 区药学3 区医学：研究与实验3 区生化与分子生物学
最新[2025]版：
大类|3 区医学
小类|3 区生化与分子生物学3 区医学：研究与实验3 区药学
第一作者：
第一作者机构：[1]Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hung Hom, Hong Kong[2]Mental Health Research Center, Hong Kong Polytechnic University, Hung Hom, Hong Kong
共同第一作者：
通讯作者：
通讯机构：[1]Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hung Hom, Hong Kong[2]Mental Health Research Center, Hong Kong Polytechnic University, Hung Hom, Hong Kong
推荐引用方式(GB/T 7714)：
Formolo Douglas A,Lee Thomas H,Yu Jiasui,et al.Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity[J].Biomedicines.2023,11(2):doi:10.3390/biomedicines11020249.
APA：
Formolo Douglas A,Lee Thomas H,Yu Jiasui,Lin Kangguang,Chen Gang...&Yau Suk-Yu.(2023).Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity.Biomedicines,11,(2)
MLA：
Formolo Douglas A,et al."Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity".Biomedicines 11..2(2023)
