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Diagnostic performance and prognostic value of circulating tumor DNA methylation marker in extranodal natural killer/T cell lymphoma

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收录情况： ◇ SCIE

作者：
Tian Xiao-Peng[1,2] * ; Zhang Yu-Chen[1,2] * ; Lin Ning-Jing[3] * ; Wang Liang[4] * ; Li Zhi-Hua[5] * ; Guo Han-Guo[6] ; Ma Shu-Yun[1,2] ; An Ming-Jie[7] ; Yang Jing[4] ; Hong Yu-Heng[8] ; Wang Xian-Huo[8] ; Zhou Hui[9] ; Li Ya-Jun[9] ; Rao Hui-Lan[10] ; Li Mei[10] ; Hu Shao-Xuan[3] ; Lin Tong-Yu[1,2] ; Li Zhi-Ming[1,2] ; Huang He[1,2] ; Liang Yang[11] ; Xia Zhong-Jun[11] ; Lv Yue[11] ; Liu Yu-Ying[2] ; Duan Zhao-Hui[12] ; Chen Qing-Yu[13] ; Wang Jin-Ni[1,2] ; Cai Jun[1,2] ; Xie Ying[14] ; Ong Choon-Kiat[15] ; Liu Fang[16] ; Liu Yan-Yan[17] ; Yan Zheng[17] ; Huang Liang[18] ; Tao Rong[19] ; Li Wen-Yu[7] ; Huang Hui-Qiang[1,2] ; Cai Qing-Qing[1,2] ;
机构： [1]Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China [2]State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China [3]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, P.R. China [4]Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, P.R. China [5]Department of Oncology, Sun Yat-sen Memorial Hospital, Guangzhou, Guangdong, P. R. China [6]Division of Lymphoma, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, P.R. China [7]Department of Urology, Sun Yat-sen Memorial Hospital, Guangzhou, P.R. China [8]Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P.R. China [9]Department of Lymphoma and Hematology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P.R. China [10]Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China [11]Department of Hematology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China [12]Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Guangzhou, P.R. China [13]Department of Medical Examination Center, Sun Yat-sen Memorial Hospital, Guangzhou, P.R. China [14]Guangdong Provincial Academy of Chinese Medical Sciences, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, P.R. China [15]Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Drive, 169610 Singapore, Singapore [16]Department of Pathology, The First People’s Hospital of Foshan, Foshan, P.R. China [17]Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, 127 Dongming Road, Zhengzhou 450008, P.R. China [18]Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China [19]Department of Lymphoma, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
出处：
DOI： 10.1016/j.xcrm.2022.100859
ISSN：

摘要：
Circulating tumor DNA (ctDNA) carries tumor-specific genetic and epigenetic variations. To identify extranodal natural killer/T cell lymphoma (ENKTL)-specific methylation markers and establish a diagnostic and prognosis prediction model for ENKTL, we describe the ENKTL-specific ctDNA methylation patterns by analyzing the methylation profiles of ENKTL plasma samples. We construct a diagnostic prediction model based on ctDNA methylation markers with both high specificity and sensitivity and close relevance to tumor staging and therapeutic response. Subsequently, we built a prognostic prediction model showing excellent performance, and its predictive accuracy is significantly better than the Ann Arbor staging and prognostic index of natural killer lymphoma (PINK) risk system. Notably, we further establish a PINK-C risk grading system to select individualized treatment for patients with different prognostic risks. In conclusion, these results suggest that ctDNA methylation markers are of great value in diagnosis, monitoring, and prognosis, which might have implications for clinical decision-making of patients with ENKTL.Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
We thank Kang Zhang (Center for Biomedicine and Innovations, Faculty of Medicine, Macau University of Science and Technology and University Hospital) and Gen Li (Guangzhou Women and Children’s Medical Center) for manuscript consultation, technical support, and sample processing. This work was supported by grants from the National Key Research and Development Program (2022YFC2502602), the National Natural Science Foundation of China (82230001 and 82270199), the Sun Yat-Sen University Clinical Research 5010 Program (2020009), the Special Support Program of Sun Yat-sen University Cancer Center (PT19020401), and the Clinical Oncology Foundation of Chinese Society of Clinical Oncology (Y-XD2019-124 and Y-SY2021ZD-0110).
语种：
外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 医学：研究与实验 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 医学：研究与实验 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China [2]State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China [2]State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China
推荐引用方式(GB/T 7714)：
Tian Xiao-Peng,Zhang Yu-Chen,Lin Ning-Jing,et al.Diagnostic performance and prognostic value of circulating tumor DNA methylation marker in extranodal natural killer/T cell lymphoma[J].CELL REPORTS MEDICINE.2023,4(2):doi:10.1016/j.xcrm.2022.100859.
APA：
Tian Xiao-Peng,Zhang Yu-Chen,Lin Ning-Jing,Wang Liang,Li Zhi-Hua...&Cai Qing-Qing.(2023).Diagnostic performance and prognostic value of circulating tumor DNA methylation marker in extranodal natural killer/T cell lymphoma.CELL REPORTS MEDICINE,4,(2)
MLA：
Tian Xiao-Peng,et al."Diagnostic performance and prognostic value of circulating tumor DNA methylation marker in extranodal natural killer/T cell lymphoma".CELL REPORTS MEDICINE 4..2(2023)

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