机构：[1]Institute of Scientific Research, Southern Medical University, Guangzhou, P.R. China[2]TCM-Integrated Hospital, Southern Medical University, Guangzhou, P.R. China[3]NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China[4]Boehringer-Ingelheim, Connecticut, P.R. USA[5]Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China
Oral administration is the preferred route for drug administration that leads to better therapy compliance. The intestine plays a key role in the absorption and metabolism of oral drugs, therefore, new intestinal models are being continuously proposed, which contribute to the study of intestinal physiology, drug screening, drug side effects, and drug-drug interactions.Advances in pharmaceutical processes have produced more drug formulations, causing challenges for intestinal models. To adapt to the rapid evolution of pharmaceuticals, more intestinal models have been created. However, because of the complexity of the intestine, few models can take all aspects of the intestine into account, and some functions must be sacrificed to investigate other areas. Therefore, investigators need to choose appropriate models according to the experimental stage and other requirements to obtain the desired results.To help researchers achieve this goal, this review summarised the advantages and disadvantages of current commonly used intestinal models and discusses possible future directions, providing a better understanding of intestinal models.
基金：
This work was supported by the National Natural Science Foundation of
China (grant 82204499, 82074110, 81873080), the Open Project of State
Key Laboratory of Natural Medicines (grant SKLNMKF202209), Funding
by Science and Technology Projects in Guangzhou (grant
202201011117) and Pharmacy Project of Guangdong Province Hospital
Association (grant 2021YXQN01).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|4 区医学
小类|4 区药学4 区毒理学
最新[2025]版：
大类|4 区医学
小类|4 区药学4 区毒理学
第一作者：
第一作者机构：[1]Institute of Scientific Research, Southern Medical University, Guangzhou, P.R. China[2]TCM-Integrated Hospital, Southern Medical University, Guangzhou, P.R. China
共同第一作者：
通讯作者：
通讯机构：[2]TCM-Integrated Hospital, Southern Medical University, Guangzhou, P.R. China[5]Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China[*1]TCM-Integrated Hospital, Southern Medical University, Guangzhou, P.R. China[*2]Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China
推荐引用方式(GB/T 7714)：
Chen Jinyuan,Yuan Ziyun,Tu Yifan,et al.Experimental and computational models to investigate intestinal drug permeability and metabolism[J].Xenobiotica; the fate of foreign compounds in biological systems.2023,1-21.doi:10.1080/00498254.2023.2180454.
APA：
Chen Jinyuan,Yuan Ziyun,Tu Yifan,Hu Wanyu,Xie Cong&Ye Ling.(2023).Experimental and computational models to investigate intestinal drug permeability and metabolism.Xenobiotica; the fate of foreign compounds in biological systems,,
MLA：
Chen Jinyuan,et al."Experimental and computational models to investigate intestinal drug permeability and metabolism".Xenobiotica; the fate of foreign compounds in biological systems .(2023):1-21
