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Integrating network analysis and experimental validation to reveal the mitophagy-associated mechanism of Yiqi Huoxue (YQHX) prescription in the treatment of myocardial ischemia/reperfusion injury

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Chen Mingtai[1,2,*1] * ; Zhong Guofu[3] * ; Liu Mengnan[2,4] * ; He Hao[5] * ; Zhou Jie[2] * ; Chen Jianping[6] ; Zhang Mingsheng[7] ; Liu Qiang[1] ; Tong Guangdong[8] ; Luan Jienan[1] ; Zhou Hua[9] ;
机构： [1]Department of Cardiovascular Disease, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, PR China [2]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao [3]Intensive Care Unit, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou university of Chinese Medicine, Shenzhen, PR China [4]National Traditional Chinese Medicine Clinical Research Base and Department of Cardiovascular, Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, Sichuan, PR China [5]State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Taipa, Macao [6]Shenzhen Key Laboratory of Hospital Chinese Medicine Preparation, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, PR China [7]School of Public Health, Guangdong Medical University, Dongguan, PR China [8]Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, PR China [9]Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou, PR China
出处：
DOI： 10.1016/j.phrs.2023.106682
ISSN：

摘要：
Myocardial ischemia/reperfusion (I/R) injury is the main cause of increasing postischemic heart failure and currently there is no definite treatment for myocardial I/R injury. It has been suggested that oxidative stress-induced mitochondrial dysfunction plays an important role in the pathological development of myocardial I/R. In this study, Yiqi Huoxue (YQHX) prescription, as a kind of Chinese herbal formula, was developed and shown to alleviate I/R injury. Network analysis combined with ultrahigh-performance liquid chromatography-high resolution mass spectrometry expounded the active components of YQHX and revealed the mitophagy-regulation mechanism of YQHX treating I/R injury. In vivo experiments confirmed YQHX significantly alleviated I/R myocardial injury and relieved oxidative stress. In vitro experiments validated that YQHX could relieve hypoxia/reoxygenation injury and attenuate oxidative stress via improving the structure and function of mitochondria, which was strongly related to regulating mitophagy. In summary, this study demonstrated that YQHX, which could alleviate I/R injury via targeting mitophagy, might be a potential therapeutic strategy for myocardial I/R injury.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

基金：
National Natural Science Foundation of China (No. 82104746); Basic and Applied Basic Research Foundation of Guangdong Province (No. 2022A1515011647); Scientific Research Project of Traditional Chinese Medicine Bureau of Guangdong Province (No. 20221354); Shenzhen Science and Technology Program (No. JCYJ20210324111213038, No. 202208183000795); Sanming Project of Medicine in Shenzhen, Guangdong Province, China (grant numbers SZZYSM202111002, SZSM201612033).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 药学
JCR分区：
出版当年[2021]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Cardiovascular Disease, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, PR China [2]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao [*1]Department of Cardiovascular Disease, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, PR China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Cardiovascular Disease, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, PR China [2]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao [*1]Department of Cardiovascular Disease, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, PR China.
推荐引用方式(GB/T 7714)：
Chen Mingtai,Zhong Guofu,Liu Mengnan,et al.Integrating network analysis and experimental validation to reveal the mitophagy-associated mechanism of Yiqi Huoxue (YQHX) prescription in the treatment of myocardial ischemia/reperfusion injury[J].PHARMACOLOGICAL RESEARCH.2023,189:doi:10.1016/j.phrs.2023.106682.
APA：
Chen Mingtai,Zhong Guofu,Liu Mengnan,He Hao,Zhou Jie...&Zhou Hua.(2023).Integrating network analysis and experimental validation to reveal the mitophagy-associated mechanism of Yiqi Huoxue (YQHX) prescription in the treatment of myocardial ischemia/reperfusion injury.PHARMACOLOGICAL RESEARCH,189,
MLA：
Chen Mingtai,et al."Integrating network analysis and experimental validation to reveal the mitophagy-associated mechanism of Yiqi Huoxue (YQHX) prescription in the treatment of myocardial ischemia/reperfusion injury".PHARMACOLOGICAL RESEARCH 189.(2023)

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