机构：[1]Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/ International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China.[2]College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.[3]Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.[5]
19-Hydroxybrevianamide M (1) and 6 R-methoxybrevianamide V (2), two new alkaloids, were isolated from an extract of the endophytic fungus Aspergillus sp. JNU18HC0517J, together with six known analogues (3- 8). Their structures were elucidated by extensive spectroscopic analyses, NMR calculations, and ECD calculations. 6 R-methoxybrevianamide V (2) was the first L-proline indole DKP alkaloid with substitution at C-6 on the proline ring. Furthermore, the cytotoxities and antimicrobial activities of these isolated compounds were also evaluated. Compound 8 exhibited moderate antibacterial activity against Staphylococcus aureus 209 P with a minimal inhibitory concentration (MIC) value of 16 µg/ml. [Figure: see text].
基金：
This work was financially supported by the National Key Research and Development Program
of China [No. 2018YFA0903200//2018YFA0903201], the National Natural Science Foundation
of China [Nos. 81925037 and 81973213], National High-level Personnel of Special Support
Program [No. 2017RA2259], the 111 Project of Ministry of Education of China [No. B13038],
Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [No.
2017BT01Y036], Guangdong International Science and Technology Cooperation Base [No.
2021A0505020015], Innovative and Research Teams Project of Guangdong Higher Education
Institution [No. 2021KCXTD001], Natural Science Foundation of Guangdong [No.
2022A1515012041], K. C. Wong Education Foundation [No. Guo-Dong Chen, 2021, China],
the Science and Technology Planning Project of Guangzhou [No. 202201020048], the
Undergraduates Innovation Project of Jinan University [No. CX21231], and the Postgraduates
Innovation Project of Jinan University [No. 2021CXB001].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|4 区医学
小类|4 区植物科学4 区应用化学4 区药学4 区药物化学
最新[2025]版：
大类|4 区医学
小类|4 区应用化学4 区药物化学4 区药学4 区植物科学
第一作者：
第一作者机构：[1]Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/ International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China.
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/ International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China.[*1]Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China[*2]College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
推荐引用方式(GB/T 7714)：
Deng Bei-Qian,Chen Ming-Qi,Wang Hong-Xiao,et al.Two new alkaloids from a strain of endophytic fungus Aspergillus sp[J].Journal of Asian natural products research.2023,1-11.doi:10.1080/10286020.2023.2173180.
APA：
Deng Bei-Qian,Chen Ming-Qi,Wang Hong-Xiao,Wang Xiao-Xia,Zhao Huan...&Gao Hao.(2023).Two new alkaloids from a strain of endophytic fungus Aspergillus sp.Journal of Asian natural products research,,
MLA：
Deng Bei-Qian,et al."Two new alkaloids from a strain of endophytic fungus Aspergillus sp".Journal of Asian natural products research .(2023):1-11
