机构：[1]National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, China[2]College of TCM, Guangdong Pharmaceutical University, Guangzhou, China[3]Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China[4]Ganzhou peopleʼs Hospital, Ganzhou, China
The bulbs of Allium sativum known as garlic are widely used as food or seasoning. In China they have been used as a traditional Chinese medicine (TCM) since ancient times for the treatment of scabies, tuberculosis, pertussis, diarrhea and dysentery. A. sativum has reportedly shown platelet aggregation inhibition and has been used in the treatment of cardiovascular diseases. However, there are only few studies focussing on the aerial parts, which are normally discarded during harvest. In this study, two new ionone glycosides, dasuanxinosides D and E (1, 2: ), are isolated from the aerial parts together with 13 known compounds including alkanes derivatives and alkyl glycosides (3 - 15: ), which are reported for the first time from this plant. Their structures are identified by extensive NMR and HRMS analyses. The isolated compounds are evaluated for their inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro.Thieme. All rights reserved.
基金：
This work was supported by the Chinese Medicine Science and Technology
Plan Project of Jiangxi Province (2020A0357), Starting Fund for
Scientific Research of High-level Talents of Gannan Medical University
(QD202009) and Key special project of “Research on modernization of
traditional Chinese medicine” in the national key R&D plan of China
(2018YFC1707100).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|3 区医学
小类|3 区药物化学3 区全科医学与补充医学3 区植物科学3 区药学
最新[2025]版：
大类|4 区医学
小类|4 区药物化学4 区全科医学与补充医学4 区药学4 区植物科学
第一作者：
第一作者机构：[1]National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, China[3]Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China
通讯作者：
通讯机构：[2]College of TCM, Guangdong Pharmaceutical University, Guangzhou, China[3]Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China[*1]Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine Heping Road 24, 150040 Harbin, China[*2]College of TCM, Guangdong Pharmaceutical University Waihuan East Road 280 – University Town, 510006 Guangzhou, China
推荐引用方式(GB/T 7714)：
Hu Bin,Hu Haibo,Pu Chuan,et al.New Ionone Glycosides from the Aerial Parts of Allium sativum and Their Anti-Platelet Aggregation Activity[J].Planta medica.2023,doi:10.1055/a-1997-5692.
APA：
Hu Bin,Hu Haibo,Pu Chuan,Peng Donghui,Wei Zheng...&Wang Qiuhong.(2023).New Ionone Glycosides from the Aerial Parts of Allium sativum and Their Anti-Platelet Aggregation Activity.Planta medica,,
MLA：
Hu Bin,et al."New Ionone Glycosides from the Aerial Parts of Allium sativum and Their Anti-Platelet Aggregation Activity".Planta medica .(2023)
