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Inhibitory effects of Patchouli alcohol on the early lifecycle stages of influenza A virus

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收录情况： ◇ SCIE

作者：
Fan Yaohua[1,2] * ; Zhang Qiong[3] * ; Zhang Wen[1] * ; Lai Yanni[4] ; Long Haishan[1] ; Huang Huiting[5] ; Zhan Shaofeng[5] ; Liu Xiaohong[5] ; Lai Jielan[6] ; Zhang Zhongde[7] ; Pan Pan[8] ; Su Ziren[9] ; Li Geng[1] ;
机构： [1]Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China. [2]Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China. [3]Guangzhou Laboratory, Guangzhou, China. [4]School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China. [5]Department of Pneumology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [6]Cancer Prevention and Treatment Center, Sun Yat-sen University, Guangzhou, China. [7]Department of Emergency, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [8]Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, The First Affiliated Hospital of Jinan University, Guangzhou, China. [9]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou, China.
出处：
DOI： 10.3389/fmicb.2022.938868
ISSN：

摘要：
The antiviral activity and underlying mechanism of Patchouli alcohol remain unclear.This study evaluated the cytotoxicity, optimal methods for drug administration, anti-influenza A activity of Patchouli alcohol. The antiviral mechanism of Patchouli alcohol was also assessed via qRT-PCR, western blot, hemagglutination inhibiting (HAI) assay, and hemolysis inhibiting assay.Patchouli alcohol was shown to have low cytotoxicity and its strongest antiviral effect was associated with premixed administration. Patchouli alcohol inhibited virus replication during the early lifecycle stages of influenza A virus infection and specifically prevented expression of the viral proteins, HA and NP. In both the HAI and hemolysis inhibiting assays, Patchouli alcohol was able to block HA2-mediated membrane fusion under low pH conditions. Patchouli alcohol had lower binding energy with HA2 than HA1.These findings suggest that Patchouli alcohol could be a promising membrane fusion inhibitor for the treatment of influenza A infection.Copyright © 2023 Fan, Zhang, Zhang, Lai, Long, Huang, Zhan, Liu, Lai, Zhang, Pan, Su and Li.

基金：
This research was funded by the National Nature Science Foundation of China (grant nos. 81973549 and 82274179), the Open Project of the State Key Laboratory of Natural Medicines (grant no. SKLNMKF201906), the Science and Technology Planning Project of Guangdong Province Office of Education (grant nos. 2019KYTD102 and 2020KZDZX1060), the Guangdong Province Key Areas R&D Plan “Lingnan Chinese Medicine Modernization (grant no. 192019082450200013), the Science,Technology and Innovation Commission of Shenzhen Municipality (grant no. JSGG20220226090550002), Shenzhen Science and Technology program (grant no. JSGG20220226090550002), and the Traditional Chinese Medicine Bureau of Guangdong Province, China (grant nos. 202111099 and 20223958).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 生物学
小类 | 2 区 微生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 3 区 微生物学
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出版当年[2021]版：
Q1 MICROBIOLOGY
最新[2023]版：
Q2 MICROBIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China. [2]Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Fan Yaohua,Zhang Qiong,Zhang Wen,et al.Inhibitory effects of Patchouli alcohol on the early lifecycle stages of influenza A virus[J].FRONTIERS IN MICROBIOLOGY.2023,13:doi:10.3389/fmicb.2022.938868.
APA：
Fan Yaohua,Zhang Qiong,Zhang Wen,Lai Yanni,Long Haishan...&Li Geng.(2023).Inhibitory effects of Patchouli alcohol on the early lifecycle stages of influenza A virus.FRONTIERS IN MICROBIOLOGY,13,
MLA：
Fan Yaohua,et al."Inhibitory effects of Patchouli alcohol on the early lifecycle stages of influenza A virus".FRONTIERS IN MICROBIOLOGY 13.(2023)

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