Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various diseases. However, complexities present in HM due to the unclear bio-active compounds, mechanisms of action, undetermined targets for therapy, and nonspecific features for metabolism, are currently an obstacle for the progression of novel drug discovery. Metabolomics could be a potential tool to overcome these issues and for the understanding of HM from a small-molecule metabolism level. The chinmedomics-based metabolomics method assesses the overall metabolism of organisms with a holistic view and shows great poten-tial for understanding metabolic pathways, evaluating curative effects, clarifying mechanisms, discovering active ingredients, and precision medicine. This re-view focuses on the efficacy evaluation, active ingredient discovery, and target exploration of HM based on metabolomics and chinmedomics.
基金：
Natural Science Foundation of State [81830110, 81903818, 81973745]
第一作者机构：[1]Heilongjiang Univ Chinese Med, Natl Chinmed Res Ctr, Dept Pharmaceut Anal, Funct Metabol Lab, Heping Rd 24, Harbin, Peoples R China
通讯作者：
通讯机构：[1]Heilongjiang Univ Chinese Med, Natl Chinmed Res Ctr, Dept Pharmaceut Anal, Funct Metabol Lab, Heping Rd 24, Harbin, Peoples R China[2]Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome, Dade Rd 111, Guangzhou, Peoples R China
推荐引用方式(GB/T 7714)：
Ren Jun-ling,Yang Le,Qiu Shi,et al.Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine[J].TRENDS IN ENDOCRINOLOGY AND METABOLISM.2023,34(3):146-157.doi:10.1016/j.tem.2023.01.005.
APA：
Ren, Jun-ling,Yang, Le,Qiu, Shi,Zhang, Ai-Hua&Wang, Xi-Jun.(2023).Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine.TRENDS IN ENDOCRINOLOGY AND METABOLISM,34,(3)
MLA：
Ren, Jun-ling,et al."Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine".TRENDS IN ENDOCRINOLOGY AND METABOLISM 34..3(2023):146-157
：
医学