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Connecting the Gut Microbiota and Neurodegenerative Diseases: the Role of Bile Acids

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机构： [1]School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan Province, China [2]The Mental Hospital of Yunnan Province, Mental Health Center affiliated to Kunming Medical University, Kunming, Yunnan Province, China [3]Department of Nursing, AnHui College of Traditional Chinese Medicine, Wuhu, Anhui Province, China [4]Department of Physical Education, Kunming Medical University, Kunming, Yunnan Province, China [5]Computer Science and Technology of Department of Science and Engineering, Shiyuan College of Nanninng Normal University, Nanning, Guangxi Province, China [6]School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong Province, China

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With the acceleration of global population aging, neurodegenerative diseases (NDs) will become the second leading cause of death in the world, which seriously threatens human life and health. Alzheimer's disease and Parkinson's disease are the most common and typical NDs. The exact mechanisms of the NDs occurrence and development remain unclear, which may be related to immune, oxidative stress, and abnormal aggregation of pathogenic proteins. Studies have suggested that gut microbiota (GM) influences brain function and plays an important role in regulating emotional and cognitive function. Recently, bile acids (BAs) have become the "star molecule" in the microbiota-gut-brain (MGB) axis research. BAs have been reported to exert anti-inflammatory, antioxidant, and neuroprotective activities in NDs. However, the role of BAs in the connection between GM and the central nervous system (CNS) is still unclear. In this review, we will review the possible mechanisms of BAs between GM and NDs and explore the function of BAs to provide ideas for the prevention and treatment of NDs in the future.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区神经科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区神经科学

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第一作者机构： [1]School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan Province, China

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通讯机构： [1]School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan Province, China [6]School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong Province, China

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