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Pinellia ternata-containing traditional Chinese medicine combined with 5-HT3RAs for chemotherapy-induced nausea and vomiting: A PRISMA-compliant systematic review and meta-analysis of 22 RCTs

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资源类型：
Pubmed体系：
作者：
Zhai Xiangyang[1,2,4] * ; He Qida[1] * ; Chen Min[1] * ; Yu Lili[1] ; Tong Chiin[1] ; Chen Ying[2] ; Wang Jue[1] ; Fan Xingxing[1] ; Xie Han[1,3,4] ; Liang Zimao[1,3,4] ; Sui Xinbing[1,3,4,*1] ; Zeng Li[1,*2] ; Wu Qibiao[1,5,6,*3] ;
机构： [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China [2]School of Health Economics and Management, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China [3]College of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China [4]Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China [5]Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong University of Technology, Guangzhou, Guangdong, China [6]Zhuhai MUST Science and Technology Research Institute, Zhuhai, Guangdong, China
出处：
DOI： 10.1016/j.phymed.2023.154823
ISSN：

摘要：
Pinellia ternata (P. ternata, Banxia)-containing traditional Chinese medicine (TCM) is widely used in China as an adjuvant treatment for chemotherapy-induced nausea and vomiting (CINV). However, evidence of its efficacy and safety remains limited.To investigate the efficacy and safety of P. ternata-containing TCM combined with 5-hydroxytryptamine-3 receptor antagonists (5-HT3RAs) in the treatment of CINV.Systematic review and meta-analysis of randomized controlled trials (RCTs).All relevant RCTs were systematically retrieved from seven internet databases (up to February 10, 2023). P. ternata-containing TCM combined with 5-HT3RAs to treat CINV was included in all RCTs. The clinical effective rate (CER) was defined as the primary outcome, while appetite, quality of life (QOL), and side effects were secondary outcomes.The meta-analysis included 22 RCTs with 1,787 patients. Our results indicated that P. ternata-containing TCM combined with 5-HT3RAs significantly improved the CER of CINV (RR = 1.46, 95% CI = 1.37-1.57, p < 0.00001), appetite (RR = 1.77, 95% CI = 1.42-2.20, p < 0.00001), QOL (RR = 7.67, 95% CI = 1.56-13.78, p = 0.01), the CER of several 5-HT3RA medications (RR = 1.47, 95% CI = 1.37-1.57, p < 0.00001), and acute and delayed vomiting (RR = 1.23, 95% CI = 1.12-1.36, p < 0.0001) compared with the 5-HT3RAs alone, while the combination therapy decreased the incidence of side effects induced by 5-HT3RAs for CINV (RR = 0.50, 95% CI = 0.42-0.59, p < 0.00001).According to the findings of this systematic review and meta-analysis, P. ternata-containing TCM combined with 5-HT3RAs was safer and more effective than 5-HT3RAs alone for CINV patients. However, due to the limitations of the included studies, more high-quality clinical trials are required to further validate our findings.Copyright © 2023 Elsevier GmbH. All rights reserved.

基金：
This work was supported by the Science and Technology Development Fund, Macau SAR (File No.: 0099/2018/A3, and 0098/2021/A2), Science and Technology Planning Project of Guangdong Province (2020B1212030008).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 药学 1 区 全科医学与补充医学 1 区 植物科学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
第一作者：
第一作者机构： [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China [2]School of Health Economics and Management, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China [4]Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China
共同第一作者：
通讯作者：
通讯机构： [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China [3]College of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China [4]Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China [5]Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong University of Technology, Guangzhou, Guangdong, China [6]Zhuhai MUST Science and Technology Research Institute, Zhuhai, Guangdong, China [*1]School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, 311121 Hangzhou, Zhejiang, China [*2]State Key Laboratory of Quality Research in Chinese Medicine and Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, 999078 Macau, China. [*3]ate Key Laboratory of Quality Research in Chinese Medicine, and Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, 999078 Macau, China.
推荐引用方式(GB/T 7714)：
Zhai Xiangyang,He Qida,Chen Min,et al.Pinellia ternata-containing traditional Chinese medicine combined with 5-HT3RAs for chemotherapy-induced nausea and vomiting: A PRISMA-compliant systematic review and meta-analysis of 22 RCTs[J].Phytomedicine : international journal of phytotherapy and phytopharmacology.2023,115:154823.doi:10.1016/j.phymed.2023.154823.
APA：
Zhai Xiangyang,He Qida,Chen Min,Yu Lili,Tong Chiin...&Wu Qibiao.(2023).Pinellia ternata-containing traditional Chinese medicine combined with 5-HT3RAs for chemotherapy-induced nausea and vomiting: A PRISMA-compliant systematic review and meta-analysis of 22 RCTs.Phytomedicine : international journal of phytotherapy and phytopharmacology,115,
MLA：
Zhai Xiangyang,et al."Pinellia ternata-containing traditional Chinese medicine combined with 5-HT3RAs for chemotherapy-induced nausea and vomiting: A PRISMA-compliant systematic review and meta-analysis of 22 RCTs".Phytomedicine : international journal of phytotherapy and phytopharmacology 115.(2023):154823

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