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Monoterpenoid indole alkaloid adducts and dimers from Melodinus fusiformis

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资源类型：
Pubmed体系：
作者：
Liu Zhi-Wen[1] * ; Song Min[3,4] ; Wang Jun-Ya[1,2] ; Wang De-Zhi[1,2] ; Sun Biao[1,2] ; Shi Lei[1,2] ; Jiang Ren-Wang[1] ; Ma Min[3,4,*2] ; Zhang Xiao-Qi[1,2,*1] ;
机构： [1]Guangdong Provincial Engineering Research Center for Modernization of TCM, Jinan University, Guangzhou, 510632, PR China [2]NMPA Key Laboratory for Quality Evaluation of TCM, Jinan University, Guangzhou, 510632, PR China [3]School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, PR China [4]The First Affiliated Hospital of Jinan University, Guangzhou, 510630, PR China
出处：
DOI： 10.1016/j.phytochem.2023.113678
ISSN：

摘要：
Eight unprecedented monoterpenoid indole alkaloid (MIA) adducts and dimers, melofusinines A-H (1-8), and three undescribed melodinus-type MIA monomers, melofusinines I-K (9-11), together with six putative biogenetic precursors were isolated from the twigs and leaves of Melodinus fusiformis Champ. ex Benth. Compounds 1 and 2 are unusual hybrid indole alkaloids incorporating an aspidospermatan-type MIA with a monoterpenoid alkaloid unit via C-C coupling. Compounds 3-8 feature the first MIA dimers constructed through an aspidospermatan-type monomer and a rearranged melodinus-type monomer with two different types of couplings. Their structures were elucidated by spectroscopic data, single crystal X-ray diffraction, and calculated electric circular dichroism spectra analysis. In addition, dimers 5 and 8 showed significant neuroprotection effects on MPP +-injured primary cortical neurons.Copyright © 2023 Elsevier Ltd. All rights reserved.

基金：
This research was supported by the National Natural Science Foundation of China (Nos. U1801287, 82073712, 82074430), the Science and Technology Key Project of Guangdong Province (Nos. 2017BT01Y036, 2020B1111110004), Science and Technology Planning Project of Guangzhou City (No. 20212210005), and the High-performance Super Computing Platform of Jinan University
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 生物学
小类 | 2 区 植物科学 2 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
第一作者：
第一作者机构： [1]Guangdong Provincial Engineering Research Center for Modernization of TCM, Jinan University, Guangzhou, 510632, PR China
通讯作者：
通讯机构： [1]Guangdong Provincial Engineering Research Center for Modernization of TCM, Jinan University, Guangzhou, 510632, PR China [2]NMPA Key Laboratory for Quality Evaluation of TCM, Jinan University, Guangzhou, 510632, PR China [3]School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, PR China [4]The First Affiliated Hospital of Jinan University, Guangzhou, 510630, PR China [*1]Guangdong Provincial Engineering Research Center for Modernization of TCM, Jinan University, Guangzhou, 510632, PR China. [*2]School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, PR China
推荐引用方式(GB/T 7714)：
Liu Zhi-Wen,Song Min,Wang Jun-Ya,et al.Monoterpenoid indole alkaloid adducts and dimers from Melodinus fusiformis[J].Phytochemistry.2023,211:113678.doi:10.1016/j.phytochem.2023.113678.
APA：
Liu Zhi-Wen,Song Min,Wang Jun-Ya,Wang De-Zhi,Sun Biao...&Zhang Xiao-Qi.(2023).Monoterpenoid indole alkaloid adducts and dimers from Melodinus fusiformis.Phytochemistry,211,
MLA：
Liu Zhi-Wen,et al."Monoterpenoid indole alkaloid adducts and dimers from Melodinus fusiformis".Phytochemistry 211.(2023):113678

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