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A miRNA-205-based model for prediction of the recurrence of endometrioid endometrial cancer

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作者：
Gan Yaping[1,2] * ; Feng Weifeng[3] * ; Xu Liben[4] ; Guo Xinwei[5] ; Wang Yan[4] ; Chen Zhifu[1,4] ; Zhu Lihua[4] ; Wu Chaoyang[4,*2] ; Ning Yingxia[1,*1] ;
机构： [1]Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Jinan University Guangzhou 510632, Guangdong, China. [2]Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510632, Guangdong, China. [3]Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510632, Guangdong, China. [4]Department of Radiotherapy, Jiangsu University Affiliated People's Hospital Zhenjiang 212000, Jiangsu, China. [5]Department of Radiotherapy, Yangzhou University Affiliated Taixing People's Hospital Taixing 225400, Jiangsu, China.
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关键词： Endometrioid endometrial cancer miRNA-205 risk score recurrence

摘要：
To develop a miRNA-205 based model for prediction of the recurrence of endometrial cancer.The FIGO (International Federation of Gynecology and Obstetrics) stage, grading, myometrial infiltration, lymph node status and miRNA-205 expression levels were extracted from 90 endometrioid endometrial cancer patients, recurrence related risk factors were analyzed by Cox regression analysis. A risk model was then developed.A total of 90 endometrial cancer patients were retrospectively included for the analysis. The FIGO stage and expression levels of miRNA 205 were independently associated with the recurrence-free survival of the patients. The FIGO stage and expression levels of miRNA 205 were used for a prognostic model of recurrence-free survival. The c-index of the model reached 0.764, and the output of the model (risk score) could stratify the patients into different groups on the risk of recurrence.A miRNA-205 based model could predict the risk of recurrence for endometrioid endometrial cancer, and the model could provide a risk stratification of patients by recurrence risk.AJTR Copyright © 2023.

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出版当年[2022]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 医学：研究与实验
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验 4 区 肿瘤学
第一作者：
第一作者机构： [1]Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Jinan University Guangzhou 510632, Guangdong, China. [2]Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510632, Guangdong, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Jinan University Guangzhou 510632, Guangdong, China. [4]Department of Radiotherapy, Jiangsu University Affiliated People's Hospital Zhenjiang 212000, Jiangsu, China. [*1]Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Jinan University, No. 613, West Huangpu Avenue, Tianhe District, Guangzhou 510-632, Guangdong, China [*2]Department of Radiotherapy, Jiangsu University Affiliated People’s Hospital, No. 438, Jiefang Road, Jingkou District, Zhenjiang 212000, Jiangsu, China
推荐引用方式(GB/T 7714)：
Gan Yaping,Feng Weifeng,Xu Liben,et al.A miRNA-205-based model for prediction of the recurrence of endometrioid endometrial cancer[J].American journal of translational research.2023,15(3):1990-1995.
APA：
Gan Yaping,Feng Weifeng,Xu Liben,Guo Xinwei,Wang Yan...&Ning Yingxia.(2023).A miRNA-205-based model for prediction of the recurrence of endometrioid endometrial cancer.American journal of translational research,15,(3)
MLA：
Gan Yaping,et al."A miRNA-205-based model for prediction of the recurrence of endometrioid endometrial cancer".American journal of translational research 15..3(2023):1990-1995

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