个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Yang Shu[1,2,7] * ; Xiang Jiaqing[1,7] * ; Ma Chuanrui[3,4] * ; Yang Guangyan[1,2,7] ; Wang Xinyu[1,7] ; Liu Hanyong[5,7] ; Fan Guanwei[3,4] ; Kang Lin[1,2,6,7] ; Liang Zhen[1,2,7] ;
机构： [1]Department of Geriatrics, The First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People’s Hospital), Shenzhen, Guangdong 518020, China [2]Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University ,The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong 518020, China [3]First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China [4]Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China [5]Department of Nephrology, The First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People’s Hospital), Shenzhen, Guangdong 518020, China [6]The Biobank of National Innovation Center for Advanced Medical Devices, Shenzhen People’s Hospital, Shenzhen, Guangdong 518020, China [7]Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University ,The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China
出处：
DOI： 10.1016/j.celrep.2023.112367
ISSN：

摘要：
Transforming growth factor β (TGF-β) is the primary factor that drives fibrosis in most forms of chronic kidney disease. The aim of this study was to identify endogenous regulators of TGF-β signaling and fibrosis. Here, we show that tubulointerstitial fibrosis is aggravated by global deletion of KLF13 and attenuated by adeno-associated virus-mediated KLF13 overexpression in renal tubular epithelial cells. KLF13 recruits a repressor complex comprising SIN3A and histone deacetylase 1 (HDAC1) to the TGF-β target genes, limiting the profibrotic effects of TGF-β. Temporary upregulation of TGF-β induces KLF13 expression, creating a negative feedback loop that triggers the anti-fibrotic effect of KLF13. However, persistent activation of TGF-β signaling reduces KLF13 levels through FBXW7-mediated ubiquitination degradation and HDAC-dependent mechanisms to inhibit KLF13 transcription and offset the anti-fibrotic effect of KLF13. Collectively, our data demonstrate a role of KLF13 in regulating TGF-β signaling and fibrosis.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
This work was supported by grants from the National Natural Science Foundation of China, China (82000824 to S.Y., 82003747 to C.M., 82170842 to Z.L., and 82171556 to L.K.); the Natural Science Foundation of Shenzhen City, China (KCXFZ20201221173600001to Z.L.); the National Key Research and Development Program of China, China (2018YFC2001100), and the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine, China (ZYYCXTD-C-202203; ZYYCXTD-D-202207).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Geriatrics, The First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People’s Hospital), Shenzhen, Guangdong 518020, China [2]Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University ,The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong 518020, China [7]Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University ,The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Geriatrics, The First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People’s Hospital), Shenzhen, Guangdong 518020, China [2]Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University ,The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong 518020, China [3]First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China [4]Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China [6]The Biobank of National Innovation Center for Advanced Medical Devices, Shenzhen People’s Hospital, Shenzhen, Guangdong 518020, China [7]Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University ,The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China
推荐引用方式(GB/T 7714)：
Yang Shu,Xiang Jiaqing,Ma Chuanrui,et al.Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis[J].CELL REPORTS.2023,42(4):doi:10.1016/j.celrep.2023.112367.
APA：
Yang Shu,Xiang Jiaqing,Ma Chuanrui,Yang Guangyan,Wang Xinyu...&Liang Zhen.(2023).Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis.CELL REPORTS,42,(4)
MLA：
Yang Shu,et al."Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis".CELL REPORTS 42..4(2023)

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号