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Hemoporfin-mediated photodynamic therapy for the treatment of port-wine stain: A multicenter, retrospective study

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机构: [1]Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China [2]Department of Dermatology, Union Hospital, Fujian Medical University, Fuzhou, China [3]Department of Dermatology, Army Medical University (Third Military Medical University), Chongqing, China [4]Department of Hemangioma Surgery, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University, Zhengzhou, China [5]Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [6]Department of Dermatology, Affiliated Hospital Of Hebei Acadamy of Traditional Chinese Medicine, Shijiazhuang, China [7]Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China [8]Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China [9]Department of Dermatology, Shenyang Seventh People’s Hospital, Shenyang, China [10]Department of Dermatology, Huashan Hospital affiliated to Fudan University, Shanghai, China [11]Department of Photomedicine, Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China [12]Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China [13]Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China [14]Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China [15]Department of Dermatology, Xiangya Hospital of Central South University, Changsha, China [16]Department of Dermatology, Nanjing Medical University Affiliated Wuxi People’s Hospital, Wuxi, China [17]Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China [18]Dermatology Hospital of Southern Medical University, Guangzhou, China [19]Department of Dermatology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [20]Department of Dermatology, The First Hospital Of Jilin University, Changchun, China [21]Department of Dermatology and Rheumatology, Foshan Women and Children Hospital, Affiliated to Southern Medical University, Guangdong, China [22]Department of Dermatology, Shenzhen Key Medical Discipline, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, China [23]Department of Dermatology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China [24]Department of Dermatology, Chengdu Second People’s Hospital, Sichuan, China [25]Department of Cosmetic Laser Surgery, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China [26]Department of Dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, China [27]Dermatology Hospital of Jiangxi Province, Nanchang, China [28]Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China [29]Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) has been approved for port-wine stain (PWS) in China in 2017. This study evaluated the efficacy and safety of Hemoporfin-PDT for PWS in a real life setting and investigated factors that influence the efficacy.A multicenter retrospective study included patients with PWS who underwent Hemoporfin-PDT in 29 hospitals across China and completed at least two months of follow-up. The efficacy was evaluated based on patien photographs.A total of 1679 patients were included. After the first and second sessions of Hemoporfin-PDT, 63.5 and 75.3% of patients responded, respectively. The response rate of purple-type PWS was significantly lower than that of pink-type PWS (OR: 0.71, 95% CI: 0.54-0.94, P < 0.05), and there was no significant difference between thick- and pink-type (OR: 0.72, 95% CI: 0.42-1.22, P > 0.05). The response rate of PWS on the limbs was significantly lower than that on the mid-face (OR: 0.35, 95% CI: 0.23-0.53, P < 0.0001), while no significant difference was observed between PWS on the peripheral part of the face, neck or other parts of the body and PWS on the mid-face (P > 0.05). The response rate was lower in male patients with an age > 3 years or ≤ 6 years (P < 0.05). Previous treatment history did not affect the efficacy (P > 0.05). Hemoporfin-PDT was well tolerated.Patients with PWS have a good response and good tolerance to Hemoporfin-PDT.Copyright © 2023. Published by Elsevier B.V.

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大类 | 3 区 医学
小类 | 4 区 肿瘤学
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大类 | 3 区 医学
小类 | 4 区 肿瘤学
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Q3 ONCOLOGY
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第一作者机构: [1]Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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