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Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty

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Pubmed体系：
作者：
Luo Oscar Junhong[1,2] * ; Lei Wen[2,3] * ; Zhu Guodong[2,4] * ; Ren Zhiyao[1,5,6] * ; Xu Yudai[2,3] ; Xiao Chanchan[2,3] ; Zhang Hongyi[2,3] ; Cai Junxiang[7] ; Luo Zhiping[7] ; Gao Lijuan[2,3] ; Su Jun[8] ; Tang Lei[9] ; Guo Wei[9] ; Su Huanxing[3,10] ; Zhang Zhang-Jin[3,11] ; Fang Evandro Fei[3,12] ; Ruan Yijun[13] ; Leng Sean Xiao[14] ; Ju Zhenyu[15] ; Lou Huiling[7] ; Gao Junling[16] ; Peng Nan[17] ; Chen Jie[18] ; Bao Zhijun[18] ; Liu Feng[2,7] ; Chen Guobing[2,3] ;
机构： [1]Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, China. [2]Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, China. [3]Department of Microbiology and Immunology, School of Medicine Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China. [4]Department of Oncology, Guangzhou Geriatric Hospital, Guangzhou, China. [5]NHC Key Laboratory of Male Reproduction and Genetics, Guangzhou, China. [6]Department of Central Laboratory, Family Planning Research Institute of Guangdong Province, Guangzhou, China. [7]Department of Geriatrics, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China. [8]First Affiliated Hospital, Jinan University, Guangzhou, China. [9]Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China. [10]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China. [11]School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. [12]Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway. [13]The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. [14]Johns Hopkins Center on Aging and Immune Remodeling, Division of Geriatric Medicine and Gerontology, Departments of Medicine, Molecular Microbiology and Immunology, Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD, USA. [15]Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, China. [16]School of Public Health, Fudan University, Shanghai, China. [17]Department of Rehabilitation, The Second Medical Center of Chinese PLA General Hospital, Beijing, China. [18]Department of Gastroenterology, Huadong Hospital Department of Geriatrics, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
出处：
DOI： 10.1038/s43587-022-00198-9

摘要：
Frailty is an intermediate status of the human aging process, associated with decompensated homeostasis and death. The immune phenotype of frailty and its underlying cellular and molecular processes remain poorly understood. We profiled 114,467 immune cells from cord blood, young adults and healthy and frail old adults using single-cell RNA and TCR sequencing. Here we show an age-dependent accumulation of transcriptome heterogeneity and variability in immune cells. Characteristic transcription factors were identified in given cell types of specific age groups. Trajectory analysis revealed cells from non-frail and frail old adults often fall into distinct paths. Numerous TCR clonotypes were shared among T-cell subtypes in old adults, indicating differential pluripotency and resilience capabilities of aged T cells. A frailty-specific monocyte subset was identified with exclusively high expression of long noncoding RNAs NEAT1 and MALAT1. Our study discovers human frailty-specific immune cell characteristics based on the comprehensive dimensions in the immune landscape of aging and frailty.© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

基金：
This work was supported by funding from the National Key Research and Development Program of China (2021YFC2009404 to G.Z., 2018YFC2002003 to G.C., 2018YFC2002001 to J.G., 2018YFC2002002 to J.C., 2018YFC2002004 to N.P. and 2018YFC2002000 to Z.B.), the Natural Science Foundation of China (81971301 and 32050410285 to O.J.L., U1801285 to G.C., 81973221 to W.G. and 81971327 to E.F.F.), the Guangzhou Planned Project of Science and Technology (202002020039 to O.J.L., 202102010030 to G.Z. and 201904010111 to G.C.), the Initial Supporting Foundation of Jinan University (to O.J.L. and G.C.), the Milstein Medical Asian American Partnership (MMAAP) Foundation of the USA under the Irma and Paul Milstein Program for Senior Health (to G.C. and S.X.L.), the China Pharmaceutical University 2020 Innovation and Entrepreneurship Elite Cultivation Plan (to W.G.), Helse Sør-Øst (2017056 and 2020001 to E.F.F.) and the Research Council of Norway (262175 and 277813 to E.F.F.).
语种：
外文
PubmedID：
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出版当年[2021]版：
无
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 细胞生物学 1 区 老年医学 1 区 神经科学
第一作者：
第一作者机构： [1]Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, China. [2]Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, China. [2]Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, China. [3]Department of Microbiology and Immunology, School of Medicine Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China. [7]Department of Geriatrics, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Luo Oscar Junhong,Lei Wen,Zhu Guodong,et al.Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty[J].Nature aging.2022,2(4):348-364.doi:10.1038/s43587-022-00198-9.
APA：
Luo Oscar Junhong,Lei Wen,Zhu Guodong,Ren Zhiyao,Xu Yudai...&Chen Guobing.(2022).Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty.Nature aging,2,(4)
MLA：
Luo Oscar Junhong,et al."Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty".Nature aging 2..4(2022):348-364

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