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Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Liang Weijie[1] * ; Yang Yuqiong[2] * ; Gong Shenhai[3] * ; Wei Mingyuan[1] * ; Ma Yingfei[4] * ; Feng Ruipei[1] ; Gao Jingyuan[1] ; Liu Xiaomin[1] ; Tu Fuyi[5] ; Ma Wei[5] ; Yi Xinzhu[1] ; Liang Zhenyu[2] ; Wang Fengyan[2] ; Wang Lingwei[6] ; Chen Dandan[6] ; Shu Wensheng[1] ; Miller Bruce E[7] ; Tal-Singer Ruth[7] ; Donaldson Gavin C[8] ; Wedzicha Jadwiga A[8] ; Singh Dave[9] ; Wilkinson Tom M A[10] ; Brightling Christopher E[11] ; Chen Rongchang[2,6] ; Zhong Nanshan[2] ; Wang Zhang[1] ;
机构： [1]Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, Guangdong Province, China [2]First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong Province, China [3]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China [4]Shenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China [5]Institute of Statistics and Big Data, Renmin University of China, Beijing, China [6]Pulmonary and Critical Care Department, Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, Shenzhen, Guangdong Province, China [7]COPD Foundation, Washington, DC, USA [8]National Heart and Lung Institute, Imperial College London, London, UK [9]Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester University NHS Foundation Trust, Manchester, UK [10]NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK [11]Institute for Lung Health, Leicester NIHR Biomedical Research Centre, Department of Respiratory Sciences, University of Leicester, Leicester, UK
出处：
DOI： 10.1016/j.chom.2023.04.018
ISSN：

摘要：
Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression remains unknown. Here, we show, through a longitudinal analysis of two cohorts involving four UK centers, that baseline airway dysbiosis in COPD patients, characterized by the enrichment of opportunistic pathogenic taxa, associates with a rapid forced expiratory volume in 1 s (FEV1) decline over 2 years. Dysbiosis associates with exacerbation-related FEV1 fall and sudden FEV1 fall at stability, contributing to long-term FEV1 decline. A third cohort in China further validates the microbiota-FEV1-decline association. Human multi-omics and murine studies show that airway Staphylococcus aureus colonization promotes lung function decline through homocysteine, which elicits a neutrophil apoptosis-to-NETosis shift via the AKT1-S100A8/A9 axis. S. aureus depletion via bacteriophages restores lung function in emphysema mice, providing a fresh approach to slow COPD progression by targeting the airway microbiome.Copyright © 2023 Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Key R&D Program of China (2022YFA1304300) funded to Z.W., National Natural Science Foundation of China (31970112, 32170109) funded to Z.W., the Science and Technology Foundation of Guangdong Province (2019A1515011395) funded to Z.W., and the Medical Scientific Research Foundation of Guangdong Province (C2019001) funded to R.C.
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 微生物学 1 区 寄生虫学 1 区 病毒学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 微生物学 1 区 寄生虫学 1 区 病毒学
JCR分区：
出版当年[2021]版：
Q1 MICROBIOLOGY Q1 PARASITOLOGY Q1 VIROLOGY
最新[2023]版：
Q1 MICROBIOLOGY Q1 PARASITOLOGY Q1 VIROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, Guangdong Province, China
共同第一作者：
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推荐引用方式(GB/T 7714)：
Liang Weijie,Yang Yuqiong,Gong Shenhai,et al.Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease[J].CELL HOST & MICROBE.2023,31(6):1054-+.doi:10.1016/j.chom.2023.04.018.
APA：
Liang Weijie,Yang Yuqiong,Gong Shenhai,Wei Mingyuan,Ma Yingfei...&Wang Zhang.(2023).Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease.CELL HOST & MICROBE,31,(6)
MLA：
Liang Weijie,et al."Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease".CELL HOST & MICROBE 31..6(2023):1054-+

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