机构：[1]Department of Orthopedics, People’s Hospital of Pingchang County, Pingchang, Sichuan 636400, China[2]Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China[3]The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000, China深圳市中医院深圳医学信息中心[4]Department of General Surgery, People’s Hospital of Pingchang County, Pingchang, Sichuan 636400, China[5]Department of Orthopedics, Longhui People’s Hospital, Shaoyang, Hunan 422200, China[6]Department of Orthopedics, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510900, China
This study was conducted to explore the correlation of NCAP family genes with expression, prognosis, and immune infiltration in human sarcoma.Compared with normal human tissues, six NCAP family genes were highly expressed in sarcoma tissues, and high expression of the six genes were significantly associated with the poor prognosis of sarcoma patients. The expression of NCAPs in sarcoma was significantly related to the low infiltration level of macrophages and CD4+ T cells. GO and KEGG enrichment analysis showed that NCAPs and their interacting genes were mainly enriched in organelle fission for biological processes (BP), spindle for cellular component (CC), tubulin binding for molecular function (MF), and 'Cell cycle' pathway.We explored the expression of NCAP family members by ONCOMINE, and GEPIA databases. Additionally, the prognostic value of NCAP family genes in sarcoma was detected by Kaplan-Meier Plotter and GEPIA databases. Moreover, we explored the relationship between NCAP family gene expression level and immune infiltration using the TIMER database. Finally, we performed GO and KEGG analysis for NCAPs-related genes by DAVID database.The six members of NCAP gene family can be used as biomarkers to predict the prognosis of sarcoma. They were also correlated with the low immune infiltration in sarcoma.
基金：
This work was supported by Key research and development Project of the Ministry of Science and Technology in 2022: R&D and Demonstration application of key technologies of cloud-integrated visual-audio-touch multi-mode interactive feedback high simulation intelligent virtual surgery (Grant no. 2022YFF1202600).
第一作者机构：[1]Department of Orthopedics, People’s Hospital of Pingchang County, Pingchang, Sichuan 636400, China[2]Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Jiang Guangyao,Tian Qunyan,Shi Peikai,et al.Association of NCAP family genes with prognosis and immune infiltration of human sarcoma[J].AGING-US.2023,15(10):4108-4121.doi:10.18632/aging.204683.
APA：
Jiang Guangyao,Tian Qunyan,Shi Peikai,Li Zhigao,Li Yan...&Wu Gen.(2023).Association of NCAP family genes with prognosis and immune infiltration of human sarcoma.AGING-US,15,(10)
MLA：
Jiang Guangyao,et al."Association of NCAP family genes with prognosis and immune infiltration of human sarcoma".AGING-US 15..10(2023):4108-4121
