机构：[1]State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. bbding@ciac.ac.cn.[2]School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.[3]Department of Otolaryngology Head and Neck Surgery, The Second Hospital, Jilin University, Changchun 130041, China.[4]College of Pharmacy, Guangdong Medical University, Dongguan 523808, China.[5]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
As an emerging anti-tumor strategy, chemodynamic therapy (CDT) utilizes a Fenton/Fenton-like reaction to generate highly toxic hydroxyl radicals to kill tumor cells. However, the efficiency of CDT is still hindered by the low Fenton/Fenton-like reaction rate. Herein, we report the combination of ion interference therapy (IIT) and chemodynamic therapy (CDT) via an amorphous iron oxide (AIO) nanomedicine with encapsulated EDTA-2Na (EDTA). Iron ions and EDTA are released from the nanomedicine in acidic tumors and chelate to form iron ion-EDTA, which improves the efficiency of CDT and promotes the generation of reactive oxygen species (ROS). In addition, EDTA can disrupt the homeostasis of Ca2+ in tumor cells by chelating with Ca2+ ions, which induces the separation of tumor cells and affects normal physiological activities. Both in vitro and in vivo experiments show that the nano chelating drugs exhibit significant improvement in Fenton reaction performance and excellent anti-tumor activity. This study based on chelation provides a new idea for designing efficient catalysts to enhance the Fenton reaction and provides more revelations on future research on CDT.
基金：
This work is financially supported by the Science and
Technology Development Planning Project of Jilin Province
(20220508089RC), the National Natural Science Foundation of
China (Grant No. NSFC 51929201 and 52102354), the
Postdoctoral Innovative Talents Support Program (BX2021360),
the Project funded by the China Postdoctoral Science
Foundation (2021M703130 and 2021M691919), the Special
Health Project of Jilin Province (2020SCZT010) and the
Guangdong Provincial Natural Science Foundation of China
(No. 2018A030313355). All animal procedures were performed
in accordance with the Guidelines for Care and Use of
Laboratory Animals of Jilin University and approved by the
Institutional Animal Care and Use Committee of Jilin
University.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区工程技术
小类|2 区材料科学：生物材料
最新[2025]版：
大类|3 区医学
小类|3 区材料科学：生物材料
第一作者：
第一作者机构：[1]State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. bbding@ciac.ac.cn.[2]School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.
通讯作者：
通讯机构：[1]State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. bbding@ciac.ac.cn.[2]School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.
推荐引用方式(GB/T 7714)：
Chen Changxiao,Meng Qi,Liu Zhendong,et al.Iron oxide-EDTA nanoparticles for chelation-enhanced chemodynamic therapy and ion interference therapy[J].Biomaterials science.2023,doi:10.1039/d3bm00371j.
APA：
Chen Changxiao,Meng Qi,Liu Zhendong,Liu Sainan,Tong Weifang...&Lin Jun.(2023).Iron oxide-EDTA nanoparticles for chelation-enhanced chemodynamic therapy and ion interference therapy.Biomaterials science,,
MLA：
Chen Changxiao,et al."Iron oxide-EDTA nanoparticles for chelation-enhanced chemodynamic therapy and ion interference therapy".Biomaterials science .(2023)
