Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy
机构：[1]Key Lab for New Drug Research of TCM, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, China[2]Qing Hai Center for Diseases Prevention and Control, Xining 810007, Qinghai, China[3]Department of Medical Oncology, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of the Southern University of Science and Technology), Shenzhen 518020, China深圳市康宁医院深圳市人民医院深圳医学信息中心中国医科大学附属盛京医院中国医科大学盛京医院[4]Guangdong Engineering Technological Research Center for Nervous Anatomy and Related Clinical Applications, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of the Southern University of Science and Technology), Shenzhen 518020, Guangdong, China深圳市人民医院深圳医学信息中心中国医科大学附属盛京医院中国医科大学盛京医院[5]Department of neurosurgery, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of the Southern University of Science and Technology), Shenzhen 518020, Guangdong, China深圳市康宁医院深圳市人民医院深圳医学信息中心中国医科大学附属盛京医院中国医科大学盛京医院[6]Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden[7]State Key Laboratory of Fine Chemicals, Department of Pharmacology, School of Chemical Engineering, Dalian University of Technology, Dalian, China
Many approaches have been employed to relieve hypoxia in solid tumors to enhance sensitivity to radiotherapy (RT), including O2 delivery or hydrogen peroxide (H2O2) decomposition strategies. To date, however, these modalities have been restricted by poor O2 loading, rapid O2 leakage, and limited endogenous H2O2 levels. To overcome these limitations, we therefore sought to develop an effective approach for the oxygen-independent treatment of hypoxic tumors. In this study, we designed a novel black phosphorus quantum dot (BPQD)/Escherichia coli (E. coli) hybrid system (BE) capable of facilitating the photothermal therapy (PTT) of hypoxic tumors. A simple electrostatic adsorption approach was used to conjugate BPQDs to E. coli. BE is capable of reliably targeting hypoxic tumors and mediating PTT. BPQDs in BE can directly facilitate X-ray-mediated radiosensitization of tumors, thereby achieving significant RT efficacy in response to lower doses of radiation, effectively and specifically damaging hypoxic tumor tissues to suppress the growth of tumors. Our results highlight this BE system as a novel approach to tumor radiosensitization with great potential for clinical application.
基金：
We are grateful for the financial support by the Science,
Technology & Innovation Commission of Shenzhen
Municipality (No. JCYJ20190808154213097), and the Natural
Science Foundation of Guangdong Province
(2020A1515010400).
第一作者机构：[1]Key Lab for New Drug Research of TCM, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, China[3]Department of Medical Oncology, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of the Southern University of Science and Technology), Shenzhen 518020, China[4]Guangdong Engineering Technological Research Center for Nervous Anatomy and Related Clinical Applications, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of the Southern University of Science and Technology), Shenzhen 518020, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]Key Lab for New Drug Research of TCM, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, China[7]State Key Laboratory of Fine Chemicals, Department of Pharmacology, School of Chemical Engineering, Dalian University of Technology, Dalian, China
推荐引用方式(GB/T 7714)：
Ji Pengchao,Chen Jinghua,Wang Hao,et al.Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy[J].BIOMATERIALS SCIENCE.2023,11(13):4727-4740.doi:10.1039/d3bm00206c.
APA：
Ji Pengchao,Chen Jinghua,Wang Hao,Shi Linfei,Tang Xudong&Duo Yanhong.(2023).Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy.BIOMATERIALS SCIENCE,11,(13)
MLA：
Ji Pengchao,et al."Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy".BIOMATERIALS SCIENCE 11..13(2023):4727-4740
