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The role of placental aging in adverse pregnancy outcomes: A mitochondrial perspective

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收录情况： ◇ SCIE

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机构： [1]Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China [2]The Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China [3]The Academy of Integrative Medicine of Fudan University, Shanghai, China [4]Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China [5]Center for Reproductive Medicine, Zhoushan Women and Children Hospital, Zhejiang, China

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摘要：

Premature placental aging is associated with placental insufficiency, which reduces the functional capacity of the placenta, leading to adverse pregnancy outcomes. Placental mitochondria are vital organelles that provide energy and play essential roles in placental development and functional maintenance. In response to oxidative stress, damage, and senescence, an adaptive response is induced to selectively remove mitochondria through the mitochondrial equivalent of autophagy. However, adaptation can be disrupted when mitochondrial abnormalities or dysfunctions persist. This review focuses on the adaptation and transformation of mitochondria during pregnancy. These changes modify placental function throughout pregnancy and can cause complications. We discuss the relationship between placental aging and adverse pregnancy outcomes from the perspective of mitochondria and potential approaches to improve abnormal pregnancy outcomes.Copyright © 2023 Elsevier Inc. All rights reserved.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 2 区医学：研究与实验 2 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区药学 3 区医学：研究与实验

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出版当年[2021]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 5.2 最新[2023版] 5.3 最新五年平均 6.78 出版当年[2021版] 6.044 出版当年五年平均 5.037 出版前一年[2020版] 6.1 出版后一年[2022版]

第一作者：

第一作者机构： [1]Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China [2]The Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China [3]The Academy of Integrative Medicine of Fudan University, Shanghai, China [4]Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China

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通讯作者：

通讯机构： [1]Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China [3]The Academy of Integrative Medicine of Fudan University, Shanghai, China [4]Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China [*1]Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai 200011, China.

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