高级检索
当前位置: 首页 > 详情页

Discovery of two ent-atisane diterpenoid lactones with AChE inhibitory activity from the roots of Euphorbia fischeriana

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518035, Guangdong, Peoples R China [2]Ningbo Coll Hlth Sci, Wu Zhengzhi Academician Workstat, Ningbo 315800, Zhejiang, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China [4]Beijing Univ Tradit Chinese Med, Dongzhimen Hosp, Beijing 100007, Peoples R China [5]Beijing Univ Chinese Med, Beijing 100105, Peoples R China
出处:
ISSN:

摘要:
Euphorlactone A (1), a rare rearranged ent-atisane norditerpenoid with an undescribed 3-nor-2,4-olideent-atisane scaffold, and euphorlactone B (2), a new ent-atisane diterpenoid with an unprecedented seven-membered lactone ring C, were isolated from the roots of Euphorbia fischeriana. Their planar structures with absolute configurations were extensively elucidated by analysis of 1D and 2D NMR data, electronic circular dichroism (ECD) calculations, Rh-2(OCOCF3)(4)(-)induced ECD curves, and single-crystal X-ray diffraction. Euphorlactone A (ELA) showed a remarkable AChE (acetylcholinesterase) inhibitory activity (IC50 = 2.13 +/- 0.06 mu M and K-i = 0.058 mu M), which was five times stronger than that of the positive control (rivastigmine, IC50 = 12.46 +/- 0.82 mu M), and further in vitro enzyme inhibition kinetic analysis and molecular docking studies were performed to investigate the AChE inhibitory mechanism.

基金:
语种:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2022]版:
大类 | 3 区 化学
小类 | 2 区 有机化学
最新[2025]版:
大类 | 3 区 化学
小类 | 3 区 有机化学
JCR分区:
出版当年[2021]版:
Q1 CHEMISTRY, ORGANIC
最新[2024]版:
Q2 CHEMISTRY, ORGANIC

影响因子: 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者:
第一作者机构: [1]Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518035, Guangdong, Peoples R China [2]Ningbo Coll Hlth Sci, Wu Zhengzhi Academician Workstat, Ningbo 315800, Zhejiang, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
共同第一作者:
通讯作者:
通讯机构: [1]Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518035, Guangdong, Peoples R China [2]Ningbo Coll Hlth Sci, Wu Zhengzhi Academician Workstat, Ningbo 315800, Zhejiang, Peoples R China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:2023 今日访问量:0 总访问量:648 更新日期:2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持:重庆聚合科技有限公司 地址:广州市越秀区大德路111号