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Wogonin inhibits oxidative stress and vascular calcification via modulation of heme oxygenase-1

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Lu Lihe[1] * ; Li Yining[2,3] * ; Dong Qian[4] * ; Fang Jiansong[5] ; Chen An[2,3] ; Lan Zirong[2,3] ; Ye Yuanzhi[2,3] ; Yan Jianyun[2,3,*2] ; Liang Qingchun[6,*1] ;
机构： [1]Department of Pathophysiology, Zhongshan Medical School, Sun Yat-Sen University, Guangzhou, China [2]Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China [3]Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, China [4]Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, China [5]Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China [6]Department of Anesthesiology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China
出处：
DOI： 10.1016/j.ejphar.2023.176070
ISSN：

关键词： Vascular calcification Systems pharmacology Wogonin Heme oxygenase-1 Oxidative stress Reactive oxygen species

摘要：
Vascular calcification (VC) is highly prevalent and increases the morbidity and mortality of cardiovascular diseases. However, the underlying mechanism remains unclear and there is no effective treatment so far. Interestingly, using systems pharmacology approach, we have predicted that Wogonin (Wog) exhibited potential activity against VC. Then we validated the effect of Wog on VC using human and rat vascular smooth muscle cells (VSMCs), rat arterial rings and vitamin D3-overloaded mouse models. Our results showed that Wog dose-dependently inhibited calcification of VSMCs and rat arterial rings. Consistently, alizarin red staining and calcium content assay confirmed that Wog inhibited aortic calcification in vitamin D3-overloaded mice. Moreover, by constructing the protein regulating network of Wog in suppressing VC, we found heme oxygenase-1 (HMOX-1) was regulated by Wog. Additionally, pathway enrichment analysis revealed that inhibition of reactive oxygen species (ROS) pathway participated in the inhibitory role of Wog in VC and HMOX-1 was also involved in this process. Notably, our study revealed that Wog treatment promoted HMOX-1 expression, and reduced ROS levels in VSMCs. Interestingly, both inhibition of HMOX-1 by ZnPP9 and knockdown of HMOX-1 by siRNA independently eliminated the inhibitory effect of Wog on VC. Finally, administration of Wog suppressed aortic calcification in vitamin D3-overloaded mice and this effect was counteracted by ZnPP9,suggesting the crucial role of HMOX-1 in the inhibitory effect of Wog on VC. Collectively, this study combines systems pharmacology-based strategy and experiments to identify the therapeutic potential of Wog for VC via upregulating HMOX-1 and reducing oxidative stress.Copyright © 2023. Published by Elsevier B.V.

基金：
National Natural Science Foundation of China (NO. 81870190 and NO. 82170414), Basic and Applied Basic Research Foundation of Guangdong (NO. 2021A1515010752), and Guangzhou Key Laboratory of Neuropathic Pain Mechanism at Spinal Cord Level (NO. 202102100005).
语种：
外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 药学
JCR分区：
出版当年[2021]版：
Q2 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Pathophysiology, Zhongshan Medical School, Sun Yat-Sen University, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构： [2]Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China [3]Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, China [6]Department of Anesthesiology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China [*1]Department of Anesthesiology, The Third Affiliated Hospital, Southern Medical University, 183 West Zhongshan Avenue, Guangzhou, 510630, China. [*2]Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue, Guangzhou, 510280, China.
推荐引用方式(GB/T 7714)：
Lu Lihe,Li Yining,Dong Qian,et al.Wogonin inhibits oxidative stress and vascular calcification via modulation of heme oxygenase-1[J].EUROPEAN JOURNAL OF PHARMACOLOGY.2023,958:doi:10.1016/j.ejphar.2023.176070.
APA：
Lu Lihe,Li Yining,Dong Qian,Fang Jiansong,Chen An...&Liang Qingchun.(2023).Wogonin inhibits oxidative stress and vascular calcification via modulation of heme oxygenase-1.EUROPEAN JOURNAL OF PHARMACOLOGY,958,
MLA：
Lu Lihe,et al."Wogonin inhibits oxidative stress and vascular calcification via modulation of heme oxygenase-1".EUROPEAN JOURNAL OF PHARMACOLOGY 958.(2023)

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